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Flavonoids are important constituents of food and beverages and have several neuropharmacological activities. Many of these compounds are ligands for γ‐aminobutyric acid type A receptors in the central nervous system. This study aimed to investigate the anticonvulsant effects of intracerebroventricularly administered vitexin (5, 7, 4‐trihydroxyflavone‐8‐glucoside), a flavonoid found in plants, in...
J. Neurochem. (2011) 117, 623–631.
AbstractIn addition to progressive dementia, Alzheimer’s disease (AD) is characterized by increased incidence of seizure activity. Although originally discounted as a secondary process occurring as a result of neurodegeneration, more recent data suggest that alterations in excitatory‐inhibitory (E/I) balance occur in AD and may be a primary mechanism contributing...
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