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Background & Aims: Cystathionine β-synthase (CBS) deficiency causes severe hyperhomocysteinemia, which confers diverse clinical manifestations, notably liver disease. To investigate this aspect of hyperhomocysteinemia, we performed a thorough investigation of liver pathology in CBS-deficient mice, a murine model of severe hyperhomocysteinemia. Methods: The degree of liver injury and inflammation...
Background: Eicosanoids are known to modulate inflammation. Moreover, some studies report that endogenous prostaglandin E 2 (PGE 2 ) protects the pancreas against injury. Therefore, we investigated its role in a rat model of chronic alcohol consumption. Methods: Rats were fed with 20% ethanol and a corn oil-supplemented diet using the interrupted alcohol feeding regimen (EI). Controls...
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