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Increased myocardial stiffness is characteristic of many diseases, leads to a loss of diastolic function, and is a cause of diastolic heart failure (DHF). Methods to estimate myocardial stiffness include Shear Wave Elastography (SWE). Currently, ultrasound-based cardiac SWE includes acoustic radiation force (ARF)-based methods; however, the in vivo generation and detection of shear waves in myocardium...
Beside the measurement of flow velocity through mitral valve by pulsed Doppler, and measurement of velocity of myocardium by tissue Doppler imaging, estimation of diastolic function of left ventricle can also be made by measuring velocity of propagation of vortex using color Doppler M-mod imaging. Automated measurement has not become a practice yet because different methods produce different results...
Ultrasound imaging has been the modality of choice for the non-invasive assessment of cardiac function due to its real-time capacity, its fair image quality, its mobility and because it is relatively cheap. Traditionally, M- or B-mode derived volume-changes are measured to assess systolic function while blood flow patterns measured using Doppler techniques are used as an index for diastolic function...
Assessment of diastolic function with phase-contrast (PC) Magnetic Resonance Imaging (MRI) is not used in clinical routine because of the lack of automated analyses. Thus, our aim was to develop a process to automatically analyze PC data. We studied PC data of 25 controls with a custom software, designed for automated segmentation of PC images and analysis of velocity and flow rate curves to derive...
Cardiac Resynchronization Therapy (CRT) has emerged as an important therapy to improve pump function in heart failure patients with left bundle branch block (LBBB). Using a multi-scale modeling approach, we investigated the effect of mechano-electrical feedback (MEF) during LBBB and CRT on cardiac function and dispersion of repolarization. Our model describes cellular electrophysiology and calcium...
The evaluation of diastolic function from phase-contrast (PC) Magnetic Resonance (MR) data in clinical routine is not yet established. Thus, our goal was to develop a reproducible process to analyze PC data. These developments were used to estimate mitral flow and myocardial velocities from PC data of 40 controls. Besides, the reproducibility was assessed on a sub-group of 20 subjects. Transmitral...
Diastolic heart failure (DHF) is present in over 50% of hospitalized heart failure patients, and diastolic dysfunction is known to play a critical pathophysiologic role. Measurement of left-ventricular pressure (LVP) via catheterization is the gold standard for diastolic function (DF) evaluation, but current methods fail to fully capitalize on the complete information content of the pressure contour...
In this simulation study, we hypothesize that transmural heterogeneity in ion channel properties serves to homogenize cardiac workload. Mechanics and electrophysiology were modeled both on cellular and tissue level. Endo-, midmyo- and epicardial cells differed in ion channel properties only. A preload-afterload experiment was simulated to analyze cardiac pump function during normal conduction from...
The following topics are discussed: left ventricular shape evaluation; echocardiography; principal component analysis; Laplacian likelihood ratio; single photon emission computed tomography; resonance imaging; electrocardiography; cardiac resynchronization therapy; heart rate variability; whole heart model; clinical decision support; systolic and diastolic function; time frequency and time scale analysis;...
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