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Studies revealed that Nijmegen Breakage Syndrome protein 1 (NBS1) plays an important role in maintaining genome stability, but the underlying mechanism is controversial and elusive. Our results using clinical samples showed that NBS1 was involved in ataxia‐telangiectasia mutated (ATM)‐dependent pathway. NBS1 deficiency severely affected the phosphorylation of ATM as well as its downstream targets...
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