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AimTo investigate the acute and chronic effects of l‐leucine on pancreatic α‐cell function in vitro. Furthermore, we wanted to explore if glucagon‐like peptide‐1 (GLP‐1), isosteviol (ISV) and 5‐aminoimidazole‐4‐carboxamide 1‐β‐d‐ribofuranoside (AICAR) counteract changes in α‐cell function induced by chronic exposure to leucine.
MethodsIsolated mice islets were incubated with 10 mM leucine for 2 or...
The glucagon gene is expressed in α‐cells of the pancreas, L cells of the intestine and the hypothalamus. The determinants of the α‐cell‐specific expression of the glucagon gene are not fully characterized, although Arx, Pax6 and Foxa2 are critical for α‐cell differentiation and glucagon gene expression; in addition, the absence of the β‐cell‐specific transcription factors Pdx1, Pax4 and Nkx6.1 may...
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