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Objective
Head and neck squamous cell carcinoma (HNSCC) is the most common type of malignancy in the head and neck region worldwide. The therapeutic strategies for HNSCC remain unsatisfying and limited. Here, we found a population of resistant Bmi1‐expressing cells in the presence of cetuximab treatment and reported a novel role of SRY‐box transcription factor 18 (SOX18), a member of the SOX family,...
BackgroundFew human papillomavirus (HPV)(+) head and neck squamous cell carcinoma (HNSCC) cell lines exist. We established University of Michigan‐squamous cell carcinoma‐104 (UM‐SCC‐104), a new HPV(+) HNSCC cell line from a recurrent oral cavity tumor, and characterized it for the presence of cancer stem cells (CSCs).
MethodsTumor cells were tested for biomarker expression by immunohistology, and...
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