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It has been shown that the time course of echinocyte to discocyte transformation caused by exogenous phospholipids is an accurate measure of the flip rate of the phospholipids in the lipid bilayer [1,2]. In order to explore whether shape changes in erythrocytes are indicative of flip rates of water- soluble amphiphiles, the time course of shape changes caused by a large number of amphiphiles was studied...
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