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A fused pH and fluorescence sensor is proposed, and a prototype has been fabricated using CMOS silicon integrated circuit technology. Fluorescence intensity and pH can be detected at the same pixel for the first time. In the proposed device, a pH sensor which uses CCD image sensor technology and a filter-less fluorescence detection sensor are fused in the same pixel, enabling fluorescence and pH signals...
We report on several techniques that have been pursued in our laboratories for packaging complementary metal-oxide semiconductor (CMOS) sensors for use in biological environments, such as cell medium. These techniques are suited for single CMOS die ranging from 1.5 ?? 1.5 mm2 to 3 ?? 3 mm2 in area. The first method consisted of creating high aspect ratio structures from negative-tone photocurable...
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