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Focal cortical dysplasia (FCD) is an important cause of pharmacoresistant epilepsy. Small FCD lesions are difficult to distinguish from non-lesional cortex and remain often overlooked on radiological MRI inspection. This paper presents a method to detect small FCD lesions on Tl-MRI relying on surface-based features: cortical thickness, gradient magnitude at the white-matter / grey-matter interface,...
The existence of anatomical basis of functional modularity in the brain has been postulated. Previous studies in the field of theoretical neuroanatomy claimed the segregated nature of cortical areas with their physiological functions by analyzing fiber connection data of mammalian brains. The aim of this study was to investigate, using modularity-based spectral community (cluster) detection algorithm,...
The amount of experimental data concerning physiology and anatomy of the nervous system is growing very fast, challenging our capacity to make comprehensive syntheses of the plethora of data available. Computer models of neuronal networks provide useful tools to construct such syntheses. They can be used to interpret experimental data, generate experimentally testable predictions, and formulate new...
There is a trade-off in neural network simulation between simulations that embody the details of neuronal biology and those that omit these details in favor of abstractions. The former approach appeals to physiologists and pharmacologists who can directly relate their experimental manipulations to parameter changes in the model. The latter approach appeals to physicists and mathematicians who seek...
High-resolution time-frequency analyses of ictal EEG allow for identification and characterization of ictal patterns. These patterns reflect alterations in the brain network synchrony. It is not clear why seizures undergo these dynamical changes and what mechanisms contribute to or cause these changes. In this work we use neural modeling studies to address these issues. We investigate the role of...
In this paper we present three related areas of research we are pursuing to study neural computation in vitro. Rat cortical neurons cultured on 60 channel multielectrode array (MEA) allow the researcher to measure from and stimulate sixty different sites across a small population of neurons grown in vitro. Using this system we can send stimulation patterns into the network and study how these living...
The capacity of the primary visual cortex (Vl) to extract salient contours from real black-and-white images is studied using a neural network model of information processing in V1. The model includes the input from the lateral geniculate nucleus, arranged according to the preferred orientation through a Gabor function, a feedforward inhibition from inhibitory interneurons and lateral connections (both...
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