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Wild-type visinin-like-protein (VILIP) and a myristoylation-deficient VILIP mutant, when stably expressed at low levels in C6 cells, enhances or reduces the basal cAMP-level, respectively. The morphology of wild-type VlLIP-transfected cells resembles that of differentiated astrocytes, whereas the myristoylation mutant shows a phenotype similar to parental cells, but with reduced cell growth. In both...
A meeting on Wnt genes was held at Stanford University, August 9 and 10, organized by Harold Varmus (NIH) and Roel Nusse (HHMI-Stanford). This meeting was the first formal version of a series of informal Wnt gatherings held over the past years at various locations. The previous meetings were always inspired by the importance of Wnt genes in animal development and tumorigenesis, but also frustrated...
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