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We have previously proposed that pro-inflammatory cytokines and nitric oxide (NO) contributed to reversible myocardial depression in patients with sepsis and congestive heart failure. Sepsis and heart failure are also associated with refractoriness to β-adrenoceptor agonists. Therefore, the chronotropic effects of cytokines and the NO synthase inhibitor, N G -methyl-l-arginine (NMA), on...
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