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Beta-amyloid peptide is the main constituent of senile plaques and is implicated in the pathogenesis of Alzheimer's disease. It has been shown to be both neurotoxic and neurotrophic in vivo, and its effects have been suggested to be mediated in part by alterations in membrane transport. In the present study, we investigated the effect of beta-amyloid (1-40) on choline transport in cultured PC12 cells...
Phospholipase A 2 (PLA 2 ) is a key-enzyme in the metabolism of membrane phospholipids. In cholinergic neurons PLA 2 controls the physico-chemical properties of neuronal membranes as well as the breakdown of phosphatidylcholine to produce choline for acetylcholine synthesis. Moreover PLA 2 influences the processing and secretion of the amyloid precursor protein, which...
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