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article

Odontogenesis‐Empowered Extracellular Vesicles Safeguard Donor‐Recipient Stem Cell Interplay to Support Tooth Regeneration

Xiaoyao Huang, Bingdong Sui, Anqi Liu, Hao Guo, more

Small > 20 > 42 > n/a - n/a

Harnessing the developmental events of mesenchymal condensation to direct postnatal dental stem cell aggregation represents a cutting‐edge and promising approach to tooth regeneration. Tooth avulsion is among the most prevalent and serious dental injuries, and odontogenic aggregates assembled by stem cells from human exfoliated deciduous teeth (SHED) have proven effective in revitalizing avulsed teeth...

article

Testicular sclerosing stromal tumour: A report of two cases documenting GLI1 alterations

Rumeal D Whaley, Loren P Herrera Hernandez, Burak Tekin, Michael R McCarthy, more

Histopathology > 85 > 5 > 829 - 832

article

Identification of distinct subpopulations of Gli1‐lineage cells in the mouse mandible

Nian Zhang, William B. Barrell, Karen J. Liu

Journal of Anatomy > 243 > 1 > 90 - 99

The Hedgehog pathway gene Gli1 has been proposed to mark a subpopulation of skeletal stem cells (SSCs) in craniofacial bone. Skeletal stem cells (SSCs) are multi‐potent cells crucial for the development and homeostasis of bone. Recent studies on long bones have suggested that skeletal stem cells in endochondral or intramembranous ossification sites have different differentiation capacities. However,...

article

ACKR3 orchestrates Hedgehog signaling to promote renal cell carcinoma progression

Chao Tang, Lin Li, Qiang Xu, Shouying Xu, more

Molecular Carcinogenesis > 62 > 6 > 882 - 893

Renal cell carcinoma (RCC) is the second commonest urological malignant neoplasm and mortality rate of patients with RCC appears to be increasing each year. Thus, further understanding of the molecular mechanisms responsible for the development and progression of RCC is of particular importance. Here, we report that atypical chemokine receptor 3 (ACKR3) orchestrates the Hedgehog (Hh)‐GLI1 signaling...

article

Differential role of Pax6 and its interaction with Shh–Gli1–IDH2 axis in regulation of glioma growth and chemoresistance

Shirin Farheen, Swalih P. Ahmed, Mubeena Mariyath P. M., Tasneem Kausar, more

Journal of Biochemical and Molecular Toxicology > 37 > 2 > n/a - n/a

Glioma is a major brain tumor, and the associated mortality rate is very high. Contemporary therapies provide a chance of survival for 9–12 months. Therefore, a novel approach is essential to improve the survival rate. Sonic hedgehog (Shh) cell signaling is critical for early development in various tumors. This investigation attempted to explore the potential interaction and regulation of Shh–Gli1...

article

GLI1‐rearranged mesenchymal tumor in the ovary

Li Hui, Qianming Bai, Wentao Yang, Tu Xiaoyu, more

Histopathology > 81 > 5 > 688 - 692

article

Advances in periodontal stem cells and the regulating niche: From in vitro to in vivo

Yating Yi, Yinghong Liu, Yi Men, Jun Wang, more

genesis > 60 > 8-9 > n/a - n/a

Periodontium possesses stem cell populations for its self‐maintenance and regeneration, and has been proved to be an optimal stem cell source for tissue engineering. In vitro studies have shown that stem cells can be isolated from periodontal ligament, alveolar bone marrow and gingiva. In recent years, more studies have focused on identification of periodontal stem cells in vivo. Multiple genetic...

article

Ursolic acid inhibits the activation of smoothened‐independent non‐canonical hedgehog pathway in colorectal cancer by suppressing AKT signaling cascade

Li Chen, Maolun Liu, Han Yang, Shan Ren, more

Phytotherapy Research > 36 > 9 > 3555 - 3570

It is being brought to light that smoothened (SMO)‐independent non‐canonical Hedgehog signaling is associated with the pathogenesis of various cancers. Ursolic acid (UA), a pentacyclic triterpenoid present in many medicinal herbs, manifests potent effectiveness against multiple malignancies including colorectal cancer (CRC). In our previous study, UA was found to protect against CRC in vitro by suppression...

article

Deriving prognostic significance from a molecular subtype model of laryngeal carcinoma

Yibo Zhou, Jiahong Wang, Zhongxi Huang, Pinggui Gong, more

Head & Neck > 44 > 10 > 2206 - 2219

Background This study explored whether laryngeal carcinoma could be divided into different subtypes based on molecular differences using a molecular subtype‐prediction model. Methods We extracted data from the Cancer Genome Atlas and Gene Expression Omnibus databases and then performed unsupervised cluster analysis to identify discrete molecular subtypes of laryngeal carcinoma. Significance analysis...

article

Response of Gli1⁺ Suture Stem Cells to Mechanical Force Upon Suture Expansion

Dian Jing, Zexi Chen, Yi Men, Yating Yi, more

Journal of Bone and Mineral Research > 37 > 7 > 1307 - 1320

Normal development of craniofacial sutures is crucial for cranial and facial growth in all three dimensions. These sutures provide a unique niche for suture stem cells (SuSCs), which are indispensable for homeostasis, damage repair, as well as stress balance. Expansion appliances are now routinely used to treat underdevelopment of the skull and maxilla, stimulating the craniofacial sutures through...

article

Progenitor cells derived from gene‐engineered human induced pluripotent stem cells as synthetic cancer cell alternatives for in vitro pharmacology

Constanze Uhlmann, Ann‐Christin Nickel, Daniel Picard, Andrea Rossi, more

Biotechnology Journal > 17 > 6 > n/a - n/a

Limitations in genetic stability and recapitulating accurate physiological disease properties challenge the utility of patient‐derived (PD) cancer models for reproducible and translational research. A portfolio of isogenic human induced pluripotent stem cells (hiPSCs) with different pan‐cancer relevant oncoprotein signatures followed by differentiation into lineage‐committed progenitor cells was...

article

Disruption of rack1 suppresses SHH‐type medulloblastoma formation in mice

Fengjiao Liu, Jingyuan Shao, Haihong Yang, Guochao Yang, more

CNS Neuroscience & Therapeutics > 27 > 12 > 1518 - 1530

Introduction Medulloblastoma (MB) is a malignant pediatric brain tumor that arises in the cerebellar granular neurons. Sonic Hedgehog subtype of MB (SHH‐MB) is one of the major subtypes of MB in the clinic. However, the molecular mechanisms underlying MB tumorigenesis are still not fully understood. Aims Our previous work demonstrated that the receptor for activated C kinase 1 (Rack1) is essential...

article

Physalin B attenuates liver fibrosis via suppressing LAP2α–HDAC1‐mediated deacetylation of the transcription factor GLI1 and hepatic stellate cell activation

Xiaoyun Zhu, Shengtao Ye, Dongke Yu, Yanqiu Zhang, more

British Journal of Pharmacology > 178 > 17 > 3428 - 3447

Background and Purpose Liver fibrosis is one of the leading causes of morbidity and mortality worldwide but lacks any acceptable therapy. The transcription factor glioma‐associated oncogene homologue 1 (GLI1) is a potentially important therapeutic target in liver fibrosis. This study investigates the anti‐fibrotic activities and potential mechanisms of the phytochemical, physalin B. Experimental...

article

The vital role of Gli1⁺ mesenchymal stem cells in tissue development and homeostasis

Dian Jing, Chaoyuan Li, Ke Yao, Xudong Xie, more

Journal of Cellular Physiology > 236 > 9 > 6077 - 6089

The hedgehog (Hh) signaling pathway plays an essential role in both tissue development and homeostasis. Glioma‐associated oncogene homolog 1 (Gli1) is one of the vital transcriptional factors as well as the direct target gene in the Hh signaling pathway. The cells expressing the Gli1 gene (Gli1⁺ cells) have been identified as mesenchymal stem cells (MSCs) that are responsible for various tissue developments,...

article

Regulation of hepatic stellate cell contraction and cirrhotic portal hypertension by Wnt/β‐catenin signalling via interaction with Gli1

Feng Zhang, Feixia Wang, Jianlin He, Naqi Lian, more

British Journal of Pharmacology > 178 > 11 > 2246 - 2265

Background and Purpose Portal hypertension is a lethal complication of cirrhosis. Its mechanism and therapeutic targets remain largely unknown. Hepatic stellate cell (HSC) contraction increases intrahepatic vascular resistance contributing to portal hypertension. We investigated how HSC contraction was regulated by Wnt signalling and the therapeutic implications. Experimental Approach Liver tissues...

article

Primary myxoid and epithelioid mesenchymal tumor of the kidney with a novel GLI1‐FOXO4 fusion

Jason R. Pettus, Darcy A. Kerr, Radu V. Stan, Julie Y. Tse, more

Genes, Chromosomes and Cancer > 60 > 2 > 116 - 122

To our knowledge, we describe the first mesenchymal tumor with a novel GLI1‐FOXO4 fusion gene. This well‐circumscribed kidney tumor displayed variably myxoid and epithelioid histologic features with a focally nodular growth pattern. The tumor cells showed bland, round to ovoid nuclei, with no overt high‐grade features. The tumor showed focal immunopositivity for smooth muscle actin and Melan‐A, which...

article

Runx2 Regulates Mouse Tooth Root Development Via Activation of WNT Inhibitor NOTUM

Quan Wen, Junjun Jing, Xia Han, Jifan Feng, more

Journal of Bone and Mineral Research > 35 > 11 > 2252 - 2264

Progenitor cells are crucial in controlling organ morphogenesis. Tooth development is a well‐established model for investigating the molecular and cellular mechanisms that regulate organogenesis. Despite advances in our understanding of how tooth crown formation is regulated, we have limited understanding of tooth root development. Runt‐related transcription factor 2 (RUNX2) is a well‐known transcription...

article

TGF‐β/Smad2 signalling regulates enchondral bone formation of Gli1⁺ periosteal cells during fracture healing

Chenjie Xia, Qinwen Ge, Liang Fang, Huan Yu, more

Cell Proliferation > 53 > 11 > n/a - n/a

Objectives Most bone fracture heals through enchondral bone formation that relies on the involvement of periosteal progenitor cells. However, the identity of periosteal progenitor cells and the regulatory mechanism of their proliferation and differentiation remain unclear. The aim of this study was to investigate whether Gli1‐Cre^ERT2 can identify a population of murine periosteal progenitor cells...

article

Gli1 interacts with YAP1 to promote tumorigenesis in esophageal squamous cell carcinoma

Chongchong Wang, Li Cheng, Shasha Song, Shan Wu, more

Journal of Cellular Physiology > 235 > 11 > 8224 - 8235

Esophageal squamous cell carcinoma (ESCC) is the predominant esophageal cancer type in China. The aberrant activation of glioma‐associated oncogene homolog1 (Gli1), a key factor in Hedgehog (Hh) signaling pathway, has been found in esophageal carcinoma. Moreover, Yes‐associated protein 1 (YAP1), the major mediator of Hippo signaling pathway, has been linked to esophageal carcinoma progression. However,...

article

Connexin 43 Is Necessary for Murine Tendon Enthesis Formation and Response to Loading

Hua Shen, Andrea G Schwartz, Roberto Civitelli, Stavros Thomopoulos

Journal of Bone and Mineral Research > 35 > 8 > 1494 - 1503

The enthesis is a mineralized fibrocartilage transition that attaches tendon to bone and is vital for musculoskeletal function. Despite recent studies demonstrating the necessity of muscle loading for enthesis formation, the mechanisms that regulate enthesis formation and mechanoresponsiveness remain unclear. Therefore, the current study investigated the role of the gap junction protein connexin 43...

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GLI1 (168)
HEDGEHOG (30)
GLI2 (24)
SONIC HEDGEHOG (24)
GLI3 (19)
SHH (19)
HEDGEHOG PATHWAY (11)
PROGNOSIS (11)
BREAST CANCER (10)
PATCHED (10)
HEDGEHOG SIGNALING (9)
HEDGEHOG SIGNALING PATHWAY (9)
MEDULLOBLASTOMA (8)
MOUSE (8)
PTCH1 (8)
GLIOMA (6)
CANCER (5)
GLIOBLASTOMA (5)
IMMUNOHISTOCHEMISTRY (5)
PROLIFERATION (5)
SMOOTHENED (5)
Β-CATENIN (5)
COLORECTAL CANCER (4)
CYCLOPAMINE (4)
DEVELOPMENT (4)
EMT (4)
GANT61 (4)
GASTRIC CANCER (4)
IHH (4)
METHYLATION (4)
PATTERNING (4)
PTCH (4)
STEM CELLS (4)
BASAL CELL CARCINOMA (3)
CHEMORESISTANCE (3)
DIFFERENTIATION (3)
INDIAN HEDGEHOG (3)
LIMB DEVELOPMENT (3)
PANCREATIC CANCER (3)
SMALL MOLECULE (3)
SMO (3)
SONIC HEDGEHOG PATHWAY (3)
STEM CELL (3)
SUFU (3)
TOOTH (3)
VITAMIN D RECEPTOR (3)
VITAMIN D3 (3)
WNT (3)
Β‐CATENIN (3)
ACTB (2)
ADIPOCYTE DIFFERENTIATION (2)
ANGIOGENESIS (2)
APOPTOSIS (2)
BLADDER CANCER (2)
BREAST (2)
CANCER STEM CELL (2)
CD44 (2)
COLON CANCER (2)
CYP24A1 (2)
DHH (2)
DYRK1A (2)
EGCG (2)
EGFR (2)
EMBRYO (2)
ESOPHAGEAL SQUAMOUS CELL CARCINOMA (2)
ESTROGEN RECEPTOR Α (2)
GENE EXPRESSION (2)
HEPATOCELLULAR CARCINOMA (2)
HHIP (2)
HUMAN HEDGEHOG INTERACTING PROTEIN (HHIP) (2)
INTERACTION (2)
IROQUOIS (2)
IRX1 (2)
IRX2 (2)
LIVER FIBROSIS (2)
MDSCS (2)
MECHANICAL FORCE (2)
MESENCHYMAL STEM CELLS (2)
MYELINATION (2)
NEUROBLASTOMA (2)
NICHE (2)
OVARIAN CANCER (2)
P53 (2)
PACAP (2)
PATCHED 1 (2)
PATCHED1 (2)
PTC (2)
RAB23 (2)
SIGNALING (2)
SNAIL (2)
SPLICE VARIANTS (2)
TF (2)
TRA-1 (2)
TRANSCRIPTION (2)
TUMOR (2)
DROSOPHILA (1)
ABCB1 (1)
ABCG2 (1)
ACETYLATION (1)
ACKR3 (1)
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Elsevier (79)
Wiley (46)
Springer (43)

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Odontogenesis‐Empowered Extracellular Vesicles Safeguard Donor‐Recipient Stem Cell Interplay to Support Tooth Regeneration

Testicular sclerosing stromal tumour: A report of two cases documenting GLI1 alterations

Identification of distinct subpopulations of Gli1‐lineage cells in the mouse mandible

ACKR3 orchestrates Hedgehog signaling to promote renal cell carcinoma progression

Differential role of Pax6 and its interaction with Shh–Gli1–IDH2 axis in regulation of glioma growth and chemoresistance

GLI1‐rearranged mesenchymal tumor in the ovary

Advances in periodontal stem cells and the regulating niche: From in vitro to in vivo

Ursolic acid inhibits the activation of smoothened‐independent non‐canonical hedgehog pathway in colorectal cancer by suppressing AKT signaling cascade

Deriving prognostic significance from a molecular subtype model of laryngeal carcinoma

Response of Gli1⁺ Suture Stem Cells to Mechanical Force Upon Suture Expansion

Progenitor cells derived from gene‐engineered human induced pluripotent stem cells as synthetic cancer cell alternatives for in vitro pharmacology

Disruption of rack1 suppresses SHH‐type medulloblastoma formation in mice

Physalin B attenuates liver fibrosis via suppressing LAP2α–HDAC1‐mediated deacetylation of the transcription factor GLI1 and hepatic stellate cell activation

The vital role of Gli1⁺ mesenchymal stem cells in tissue development and homeostasis

Regulation of hepatic stellate cell contraction and cirrhotic portal hypertension by Wnt/β‐catenin signalling via interaction with Gli1

Primary myxoid and epithelioid mesenchymal tumor of the kidney with a novel GLI1‐FOXO4 fusion

Runx2 Regulates Mouse Tooth Root Development Via Activation of WNT Inhibitor NOTUM

TGF‐β/Smad2 signalling regulates enchondral bone formation of Gli1⁺ periosteal cells during fracture healing

Gli1 interacts with YAP1 to promote tumorigenesis in esophageal squamous cell carcinoma

Connexin 43 Is Necessary for Murine Tendon Enthesis Formation and Response to Loading

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