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Osteoarthritis (OA) is a typical joint degenerative disease that is prevalent worldwide and significantly affects the normal activities of patients. Traditional treatments using diclofenac (DCF) as an anti‐inflammatory drug by oral administration and transdermal delivery have many inherent deficiencies. In this study, a lubricating microneedles (MNs) system for the treatment of osteoarthritis with...
A crystalline porous bipyridine‐based Bpy‐COF with a high BET surface area (1864 m2 g−1) and uniform mesopore (4.0 nm) is successfully synthesized from 1,3,5‐tris‐(4’‐formyl‐biphenyl‐4‐yl)triazine and 5,5'‐diamino‐2,2'‐bipyridine via a solvothermal method. After Cu(I)‐loading, the resultant Cu(I)‐Bpy‐COF remained the ordered porous structure with evenly distributed Cu(I) ions at a single‐atom level...
The ligament, which connects bones at the joints, has both high water content and excellent mechanical properties in living organisms. However, it is still challenging to fabricate fibrous materials that possess high water content and ligament‐like mechanical characteristics simultaneously. Herein, the design and preparation of a ligament‐mimicking multicomponent fiber is reported through stepwise...
A simple, reliable method for identifying β‐lactoglobulin (β‐LG) in dairy products is needed to protect those with β‐LG allergies. A common, practical strategy for target detection is designing simplified nucleic acid nanodevices by integrating functional components. This work presents a label‐free modular β‐LG aptasensor consisting of an aptamer‐loop G‐quadruplex (G4), the working conformation of...
The volume collapse and slow kinetics reaction of anode materials are two key issues for sodium ion batteries (SIBs). Herein, an “embryo” strategy is proposed for synthesis of nanorod–embedded MoO2/MoS2/C network nanoarchitecture as anode for SIBs with high‐rate performance. Interestingly, L‐cysteine which plays triple roles including sulfur source, reductant, and carbon source can be utilized to...
Ion diffusion is a fundamentally important process in understanding and manipulating the optoelectronic properties of semiconductors. Most current studies on ionic diffusion have been focusing on perovskite polycrystalline thin films and nanocrystals. However, the random orientation and grain boundaries can heavily interfere with the kinetics of ion diffusion, where the experimental results only reveal...
In the development of nanomaterial electrodes for improved electrocatalytic activity, much attention is paid to the compositions, lattice, and surface morphologies. In this study, a new concept to enhance electrocatalytic activity is proposed by reducing impedance inside nanomaterial electrodes. Gold nanodendrites (AuNDs) are grown along silver nanowires (AgNWs) on flexible polydimethylsiloxane (PDMS)...
Tin (Sn)‐based perovskites are being investigated in many optoelectronic applications given their similar valence electron configuration to that of lead‐based perovskites and the potential environmental hazards of lead‐based perovskites. However, the formation of high‐quality Sn‐based perovskite films faces several challenges, mainly due to the easy oxidation of Sn2+ to Sn4+ and the fast crystallization...
The organic nucleation of the pharmaceutical ibuprofen is investigated, as triggered by the protonation of ibuprofen sodium salt at elevated pH. The growth and aggregation of nanoscale solution species by Analytical Ultracentrifugation and Molecular Dynamics (MD) simulations is tracked. Both approaches reveal solvated molecules, oligomers, and prenucleation clusters, their size as well as their hydration...
Oral treatment of colon diseases with the CRISPR/Cas9 system has been hampered by the lack of a safe and efficient delivery platform. Overexpressed CD98 plays a crucial role in the progression of ulcerative colitis (UC) and colitis‐associated colorectal cancer (CAC). In this study, lipid nanoparticles (LNPs) derived from mulberry leaves are functionalized with Pluronic copolymers and optimized to...
Compact but precise feature‐extracting ability is core to processing complex computational tasks in neuromorphic hardware. Physical reservoir computing (RC) offers a robust framework to map temporal data into a high‐dimensional space using the time dynamics of a material system, such as a volatile memristor. However, conventional physical RC systems have limited dynamics for the given material properties,...
A novel all‐solid‐state thin‐film lithium‐ion battery (LIB) is presented to address the trade‐off issue between the specific capacity and stabilities in a conventional LIB. Different from the conventional one, this LIB device consists of two same LIB components located at the front and back surfaces of the substrate, respectively. These two LIB components form parallel connection by using the conductive...
Graphdiyne (GDY) has garnered significant attention as a cutting‐edge 2D material owing to its distinctive electronic, optoelectronic, and mechanical properties, including high mobility, direct bandgap, and remarkable flexibility. One of the key challenges hindering the implementation of this material in flexible applications is its large area and uniform synthesis. The facile growth of centimeter‐scale...
Hydrogels possess unique polymer networks that offer flexibility/stretchability, high ionic conductivity, and resistance to electrolyte leakage, making them suitable for deformable energy storage devices. Endowing the mechanical functionality of the hydrogel electrolytes focus on either enhancing the stretchability or the toughness. However, the stretchability and the toughness are generally a trade‐off...
In inverted perovskite solar cells, conventional planar 2D/3D perovskite heterojunctions typically exhibit a type‐II band alignment, where the electric field tends to drive the electron motion in the opposite direction to the direction of electron transfer. Here, a 2D/3D gradient heterojunction is developed by allowing the 2D perovskite to infiltrate the 3D perovskite surface along the grain boundaries...
Conventional photodynamic therapy (PDT) of rheumatoid arthritis (RA) faces a dilemma: low‐power is insufficient to kill pro‐inflammatory cells while high‐power exacerbates inflammation. Herein, mitochondrial targeting is introduced in PDT of RA to implement a “less‐is‐more” strategy, where higher apoptosis in pro‐inflammatory cells are achieved with lower laser power. In arthritic rats, chlorine 6‐loaded...
Nanosized drug crystals have been reported with enhanced apparent solubility, bioavailability, and therapeutic efficacy compared to microcrystal materials, which are not suitable for parenteral administration. However, nanocrystal design and development by bottom‐up approaches are challenging, especially considering the non‐standardized process parameters in the injection step. This work aims to present...
Intrinsic or acquired radioresistance remained an important challenge in the successful management of cancer. Herein, a novel “smart” multifunctional copper‐based nanocomposite (RCL@Pd@CuZ) to improve radiotherapy (RT) sensitivity is designed and developed. In this nanoplatform, DSPE‐PEG‐RGD modified on the liposome surface enhanced tumor targeting and permeability; capsaicin inserted into the phospholipid...
The fabrication of flexible composites by integrating metal–organic frameworks (MOFs) with flexible substrates is a critical strategy for developing advanced materials with excellent feasibility and processability. These flexible MOF‐based composites play a particularly important role in the separation and purification processes. However, several drawbacks remain challenge to overcome such as long...
We study a dynamic model of price competition with differentiated products in which new generations of consumers acquire information about available products from their friends of previous generations. The social network, which links consumers across generations, affects the evolution of consumers' awareness of products and firms' long‐term (steady‐state) market shares. Focusing on steady‐state equilibria,...
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