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In this study, we present an integration routine for self-aligned ZnO nanoparticle-based thin-film transistors (TFTs) to be implemented on flexible electronics. As a proof of concept, first experiments were performed on a borosilicate glass, and subsequently the integration process was carried out on a polyethylene terephthalate (PET) substrate. The TFTs operate at low voltage (Von around 1 V) and...
In this study, a phase-change contrast agent made of biodegradable polymer PLGA and loaded with gold nanorods (GNRs) and perfluorohexane were conjugated to an anti-HER2 antibody (Herceptin) for specific binding to breast cancer cells that overexpress HER2 receptors. The mean size of the nanoparticles (NPs) was about 500 nm. The targeting specificity of PLGA-GNR-Herceptin NPs was examined using fluorescent...
Nanoparticle manipulation has a variety of potential applications, from two-dimensional material fabrication to biomedical engineering. Pattern and transportation of nanoparticles has been receiving increasing attention in recent years. Ultrasound as a mechanical wave has proven to be the most effective in the manipulation of micro-objects in a non-contact and non-invasive fashion. However, due to...
Microbubbles (MBs) are often used as ultrasound imaging contrast agents. Given their micrometer size, MBs are confined in vascular compartments because they cannot escape through endothelial barriers and, as such, MBs are primarily useful in microcirculation or vascular-targeting molecule imaging. To penetrate outside of vasculature, the size of the ultrasound contrast agent should be in the nanometer...
Self-healing and self-organization processes were studied in the magnetic polymer nanocomposites obtained on the basis of carbon nanoparticles doped with cobalt nanoclusters, synthesized by a unique technology of chemical vapor deposition (CVD) developed by the authors. These processes proceeded with the diffusion of magnetic nanoparticles stimulated by a combined effect of outer alternative and steady...
Nano-doping has a significant effect on dielectric and electrical insulation for polymer dielectrics. Pure polyimide 100HN and nano-doping polyimide 100CR from DuPont Company are adopted to conduct short-term breakdown and long-term corona-resistant experiments. The results show that, the short-term breakdown strength of 100CR is 6.4% lower than 100HN. For long-term corona resistance, the corona-resistant...
The paper presents analysis of thermal properties of natural ester modified by nanoparticles C60 and TiO2, used in power transformers. The measurements of thermal properties, such as thermal conductivity, kinematic viscosity, specific heat, density, and thermal expansion were carried out. Measurements were carried out at a temperature of 25 °C, 40 °C, 60 °C and 80 °C. On the basis of measurement results,...
Epoxy resin as a typical electrical insulation material has been widely applied in the power equipment. However, the electrical properties of epoxy resin are strongly affected by the surface charge accumulation. One way to solve the surface charge accumulation may be to use the nonlinear resistive field grading nanocomposites. In this paper, we aim to study the effect of ZnO nanoparticles on the surface...
Powders of finely dispersed cobalt ferrite were obtained by sonication. With the help of X-ray analysis, scanning electron microscopy, the influence of the initial pH of the solution and the processing conditions on the properties of the compounds formed was investigated. Samples were obtained from precursors having different pH values ranging from 7.0 to 12.0. It has been established that at pH 7–10,...
Magnetic Resonance imaging (MRI) guided focused ultrasound (FUS) has been shown to be able to safely ablate deep tissues in the brain in clinical settings resulting in reduction in recovery time and complications. Pre-clinical work has demonstrated that FUS energy deposition with intravascular micro-bubbles could be used also for non-invasive MRI-guided drug delivery into tumours and brain. The preclinical...
Nanoparticles have been required in the fields such as medicine, foods and electronic materials. By re-crystallization process, nanoparticles can be formed by quenching a solution. We have generated mono-disperse droplets by using a torsional bolt-clamped Langevin-type transducer and a micropore plate to form fine nanoparticles by quenching the droplets.
Detecting cancer at earlier stages is critical for effective therapeutic procedures and reduction of mortality. Molecular imaging plays a crucial role to improve the early diagnosis of cancer. Magneto-motive ultrasound (MMUS) imaging is a technique developed to improve the detection of magnetic nanoparticles (MNPs) by ultrasound. The advantage of using contrast agents with nanoscale dimensions is...
Composites of Low-density polyethylene (LDPE) containing 1–5 wt% of Si/SiO2 core/shell nanoparticles were fabricated by ball milling method. The neat LDPE and its composites were characterized by several experimental techniques such as DSC, SEM, BDS, AC breakdown, and erosion test to better understand the effects of Si/SiO2 nanoparticle on thermal and dielectric properties of the composites. The results...
Titania (TiO2) nanoparticles dispersed transformer oil has high Corona Inception Voltage (CIV). The volume of nanoparticles and the amount of surfactant have a strong influence on corona inception voltage. It is observed that the CIV is almost the same under high frequency AC voltage. CIV reduces with increase in level of distortion of the harmonic AC voltages. Corona generates UHF signal with its...
In Magnetomotive Ultrasound (MMUS), tissue embedded magnetic nanoparticles (NP) are mechanically excited by a magnetic field and the resulting motion of the surrounding tissue is tracked to image the NP distribution. This mechanism of excitation is of particular interest for elastography applications and offers an alternative to the acoustic radiation force excitation in order to estimate the tissue's...
In cancer treatment, there is a need to improve chemotherapeutic drug uptake at the local tumor site to both enhance dose efficacy and minimize any toxic side effects. It is well known now that stably cavitating microbubbles (MBs) in an ultrasound (US) field can increase the permeability of tumor blood vessel walls. This consequently can enhance the extravasation and accumulation of a circulating...
Nanomedicines recently gain great attention for their cancer targeting abilities and multi-functionality. Active targeting of nanoparticles with external stimuli-responsive property would improve the therapeutic efficacy and reduce harmful side effects because therapeutic effects are concentrated at the combined area of both drug and external stimuli.
Enabling detection of nanoparticles with ultrasound can open new application avenues for the ultrasound technique. Magnetomotive ultrasound (MMUS) is a technique under development which indirectly visualizes magnetic nanoparticles. In MMUS, an external time-varying magnetic field acts to displace the nanoparticles, and thus their closest surrounding. This induced displacement is subsequently detected...
Microbubbles have been widely studied as ultrasound contrast agents and drug/gene carriers. However, their short lifetime and micron-sized would hamper their applications. Mesoporous silica nanoparticles (MSNPs) with large surface areas and pore volume allow for high drug payload and controllable release feature. Our previous studies showed that superhydrophobic MSNPs can adsorb surface bubbles, which...
Microbubbles in ultrasound-triggered drug and gene delivery have been widely used for biomedical applications. However, the properties of micron-sized, short lifespan and low drug payload limit their applications. The pH sensitive nanoparticles (NPs) that can generate bubbles and release drugs quickly within acidic tumor microenvironment would be a promising theranostic agent. Among them, Amorphous...
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