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We report a highly sensitive imaging technology using surface-enhanced Raman scattering nanoparticles. Fluorescence microscopy is a well-known imaging technique which provides a specific protein distribution inside cells. However, most of currently available fluorescent organic dyes have relatively weak emission intensities and they are also photo-bleached quickly. In order to resolve this problem,...
This talk presents a new series of chiral bio-nanoclays by the modification of Cloisite Na+ with several different natural amino acids. Cloisite Na+ was swelled in water and ion exchange reactions were performed using hydrochloride salt of different amino acids. The resulting products were fully characterized by X-ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier transform infrared...
We propose mono-, di-, or tri-probe functionalized water-soluble gold nanoparticles (AuNPs) (~2 nm) based on our aqueous-phase serial solid-phase monofunctionalization (monof-) approach. They exhibit both electrical and optical sensing capabilities when specifically coupled with distinctive one- or diametric-functionality. Using ferrocene redox derivative for electrical detection scheme, the monof-,...
Because of increase in bacterial resistance to common antibiotics, antibacterial nanometallopharmaceuticals have been drawing increasing interest. Recent literature reports encouraging results about the bactericidal activity of silver nanoparticles of either a simple or composite nature. We, for the first time, demonstrated that silver nanoparticles (AgNP) undergo a shape dependant interaction with...
Single walled carbon nanotubes (SWNT) have shown tremendous promise as agents for diagnostic and therapeutic intervention in vivo. We demonstrate how Dextran sulfate (DS) can render SWNT transparent to macrophages, a vital component of the innate immunity. We also demonstrate a site specific attachment strategy to conjugate antibodies to DS for downstream applications. DS was compared to Polyethylene...
Detection of lymph node (LN) metastasis by magnetic resonance imaging (MRI) has obtained clinical significance for treating cancer patients. LN metastasis often happens through regional lymphatic system, leading to distal tumor formation including lungs, liver and bones. Successful imaging of small and microscopic LN metastasis provides the helpful information in deciding the therapeutic option of...
Poly Dimethyl Siloxane (PDMS) microneedle mold having tapered cone tips for a potential nanoparticle-based drug delivery was introduced and investigated. The fabrication of PDMS mold was performed with laser writer, which has great efficiency in repeatability and simplicity. Nanoparticles, such as polystyrene, was drop-casted at the tip of biocompatible polymers of carboxy methylcellulose (CMC) and...
Superparamagnetic magnetite (Fe3O4) nanoparticles have been widely studied for various scientific and technological applications such as magnetic storage media, contrast agents for magnetic resonance imaging (MRI), biolabelling and separation of biomolecules, and magnetic targetted drug delivery. In the absence of surface coating, Fe3O4 nanoparticles tend to aggregate due to the Van der Waals forces...
The aim of this study by performing the development of gadolinium(III) oxide(Gd2O3) nanoparticles with diethylene glycol polymer (DEG) and also by achievement of the contrast enhancement evaluation of Gd loaded nanoparticles in comparison with Magnevist (Gd-DTPA), was to indicate that Gd2O3 nanoparticles with diethylene glycol polymer could produce a good MR signal and therefore could be a useful...
Nanocomposites are recently known to be among the most successful materials in biomedical applications. In this work we sought to fabricate fibrous scaffolds which can mimic the extra cellular matrix of cartilaginous connective tissue not only to a structural extent but with a mechanical and biological analogy. Poly(3-hydroxybutyrate) (P3HB) matrices were reinforced with 5, 10 and 15 %wt hydroxyapatite...
The aim of this work was to evaluate the effect of fluorapatite (FA) nano particles content on biodegradation behavior of a nanocomposite (AZ91-FA) made of AZ91 magnesium alloy as matrix and FA nano particles as reinforcement. Bio-corrosion behavior of prepared AZ91-FA nanocomposites was evaluated. The results showed that the addition of FA nano particles to the AZ91 magnesium alloy as reinforcement...
Polyelectrolyte coated nanopatrticles (NPs) interact with bioactive molecules such as, peptides, proteins or nucleic acids and have been proposed as delivery systems for these molecules. In this study, cationic NPs were prepared by coating chitosan (CS) on the surface of PLGA NPs. The tPA encapsulated PLGA and PLGA/ CS NPs were fabricated via the W/O/W double emulsion solvent evaporation surface coating...
This study aimed at the biocompatibility evaluation of bioglass nanoparticles to chondrocyte cells using isothermal micro/nano calorimetry (IMNC), which is a new method to study cell/biomaterial interactions. For this purpose, 63S bioglass nanoparticles were made via sol-gel method and primary characterization was carried out on the particles. XRD analysis showed the amorphous structure of the glass...
The cytotoxicity of CoO nanoparticles on two micro algae (Navicula sp. and Chetoceros sp.) and Bivalve Gill cells was investigated. Cytotoxicity was determined by cellular morphological changes and LDH (Lactose Dehydrogenase), AP (Acid phosphatase) assays. It is observed that CoO nanoparticles have a detrimental effect on microalgae, promoting shrinkage and cell death. There was a significant increase...
A new probing system is proposed and developed to detect and analyze the interaction of bio materials at the molecular level. Unlike the conventional technique, when the probing method is used, the substrate is treated so that a single molecule is likely to attach to an isolated area. The substrate is micro-machined to have an Au nano-dot array with various sizes from 20 nm to 70 nm in diameter and...
Nanomaterials are becoming widely used in nanomedicine for pharmaceutical applications. This paper addresses the analysis of the possible cytotoxic effects of nanostructured materials. Specifically, the behavior of some nanoparticles against Toll-like receptors (TLRs), a class of proteins that play a key role in the innate immune system, is considered by docking analysis. The results show that the...
Chitosan microspheres (Chi-Fe microspheres) encapsulating superparamagnetic iron oxide nanoparticles (SPION, Fe3O4) were produced using a high voltage electrostatic field system. The surface morphology and size of these prepared Chi-Fe microspheres were examined using optical microscopy and scanning electron microscopy. The preliminarily results showed that the size of the Chi-Fe microspheres was...
Functionalized superparamagnetic iron oxide nanoparticles (SPIONs) can play crucial roles for medical applications such as cancer magnetic induction hyperthermia, magnetic resonance imaging and magnetofection. Herein we report the results of modified magnetic nanoparticles coated with protamine peptides containing nuclear localization signal sequences. Functionalization of these SPIONs under alternating...
The presence of enteric viruses in drinking water is a potential health risk. Growing interest has arisen in nanometals for water disinfection, in particular the use of silver based nanotechnology. In this study, Lactobacillus fermentum served as reducing agent and bacterial carrier matrix for zerovalent silver nanoparticles, referred to as biogenic Ag0. The antiviral action of biogenic Ag0 was examined...
A 10 nm nanogold particle was used to label monoclone CEA antibody to prepare an immunonanogold resonance scattering probe (AuCEAAb) for detection of CEA. In the pH 6.8 Na2HPO4-NaH2PO4 buffer solution and in the presence of PEG-6000, the immunoreaction between CEA and AuCEAAb took place to form the immunonanogold complex that can be removed by centrifugation technique. The supernatant containing AuCEAAb...
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