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The aim of this study by performing the development of gadolinium(III) oxide(Gd2O3) nanoparticles with diethylene glycol polymer (DEG) and also by achievement of the contrast enhancement evaluation of Gd loaded nanoparticles in comparison with Magnevist (Gd-DTPA), was to indicate that Gd2O3 nanoparticles with diethylene glycol polymer could produce a good MR signal and therefore could be a useful...
This paper reports a new class of biosensors based on composite nanomaterial thin film. The composite nanomaterial film is synthesized using a simple vacuum filtration method. Using composite nanomaterial film, we can not only simplify the positioning and integration fabrication process of nanoscale materials into a functional device, but also enhance the sensing surface area significantly, which...
Nanocomposites are recently known to be among the most successful materials in biomedical applications. In this work we sought to fabricate fibrous scaffolds which can mimic the extra cellular matrix of cartilaginous connective tissue not only to a structural extent but with a mechanical and biological analogy. Poly(3-hydroxybutyrate) (P3HB) matrices were reinforced with 5, 10 and 15 %wt hydroxyapatite...
Polyelectrolyte coated nanopatrticles (NPs) interact with bioactive molecules such as, peptides, proteins or nucleic acids and have been proposed as delivery systems for these molecules. In this study, cationic NPs were prepared by coating chitosan (CS) on the surface of PLGA NPs. The tPA encapsulated PLGA and PLGA/ CS NPs were fabricated via the W/O/W double emulsion solvent evaporation surface coating...
This paper presents a novel method to fabricate gold nano-particle (NP) coated PDMS waveguides for localized surface plasmon resonance (LSPR) detection of biosamples. In the presented method, PDMS optical waveguide is firstly cast in a Teflon tubing to form a cylindrical leaky waveguide structure. The de-molded PDMS optical waveguide is then modified with PDDA molecules and deposited a layer of 13...
Various nanoparticles have recently been developed for diagnostic and therapeutic use owing to the advance of nanotechnology. Nanoparticles decorated with monoclonal antibodies which showed selective binding to the intercellular cell adhesion molecule (ICAM) on the substrate were modeled. We utilized a transport-reaction model to analyze the binding characteristics of nanoparticles. Binding rate was...
This paper describes the applications of Fourier Bessel series models for characterising the transport of nanoparticles driven by dielectrophoretic forces and randomized by Brownian motion. Nanoparticle transport using dielectrophoresis continues to be an active area of research and models are fundamental for characterising the process. The models have very useful capabilities including prediction...
This paper reports a developed DNA hybridization detection method using gold-streptavidin conjugates as a reporter, the silver enhancement reaction to magnify the detection signal, and a flatbed scanner to detect the hybridization signal. There was a significant difference in grayscale between the experimental samples and the negative control after 18 min. The detection limit for a DNA sample is 8...
This study aimed at the biocompatibility evaluation of bioglass nanoparticles to chondrocyte cells using isothermal micro/nano calorimetry (IMNC), which is a new method to study cell/biomaterial interactions. For this purpose, 63S bioglass nanoparticles were made via sol-gel method and primary characterization was carried out on the particles. XRD analysis showed the amorphous structure of the glass...
This work is focused on submerged manipulation in liquid and is analyzed dynamics of the spherical nanoparticle manipulation based on Atomic Force Microscopy (AFM). In previous investigations, pushing of the nanoparticle using AFM was modeled in air and the dynamic behavior of tip and nanoparticle was investigated. Hence, as a new work the hydrodynamic force is extracted and the new dynamic modeling...
By switching the gradient fields of a clinical magnetic resonance imaging (MRI) scanner, magnetic objects may be moved inside the cardiovascular system of the human body. The main field of application is seen in targeted drug therapy or embolization. A successful navigation of such devices requires continuous position determination. The occurrence of magnetic susceptibility artifacts can be exploited...
The cytotoxicity of CoO nanoparticles on two micro algae (Navicula sp. and Chetoceros sp.) and Bivalve Gill cells was investigated. Cytotoxicity was determined by cellular morphological changes and LDH (Lactose Dehydrogenase), AP (Acid phosphatase) assays. It is observed that CoO nanoparticles have a detrimental effect on microalgae, promoting shrinkage and cell death. There was a significant increase...
Accurate size profiling on the physical sizes of aqueous nanoparticles and molecules may be affected by various factors such as the particle aggregation or the small molecular sizes. Thus, a nanoparticle exposure chamber system was constructed in which the aqueous nanoparticles are electrosprayed and dispersed into a controllable manner prior to be determined on their size distribution and concentration...
In spite of the increasing importance of manufactured nano materials, only limited information is available on the behavior of their colloidal suspensions (e.g., agglomeration, aggregation and precipitation) in the media. In this study, we investigated the effects of capping ligand concentrations (e.g. citrate and fetal bovine serum) on the colloidal stability of silver nanoparticle (nano-Ag) in relevant...
Single-nanoparticle plasmonic sensors utilizing Localized Surface Plasmon Resonance (LSPR) on a single nanoparticle has attracted increasing interesting in recent years. However, variations in plasmonic responses between different nanoparticles have not been fully studied. Here we discuss the LSPR scattering peak wavelength distribution of wet-synthesized, cetyltrimethylammonium bromide (CTAB)-capped...
Through direct deposition of Sn on a solid-supported phospholipid membrane, a monolayer of self-assembled Sn/SnOx core-shell nanoparticles was fabricated. It was demonstrated that the phase state of the lipid membrane had strong effect on the nanoparticle formation. A flexible phospholipid (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) membrane in a liquid-crystalline state allowed the metal atoms...
Gold nanoparticles have been found own broad applications in nanomaterials and nanobiotechnology for their specific physical characteristics. But generally, they are considered difficult to trap stably in optical tweezers which still owing to their specific physical characteristics. In this paper, numerical studies are carried out to show the influence of the laser parameters on the gold particles...
Spherical nanoparticles are formed and aligned in a periodic array by placing them onto nanohole array. These structures have been shown theoretically to have very narrow linewidth and improved sensitivity for biosensing applications.
Quantum dots (QDs) nanoparticles are increasingly being used for biomedical applications. Most QDs consist of heavy metal which may be potentially toxic to biological organisms. In this study, CdTe/ZnS core/shell QDs were evaluated for their harmful effects on Escherichia coli, which served as model for potential impact to microorganisms and microbial cell toxicity. Organic soluble CdTe and CdTe/ZnS...
The influences of ferrite nanoNi-Zn powders on blood and cells of rats are studied by biological and physiological methods. The ferrite nanoNi-Zn powders are made by high-temperature oxidized method, its size is 50-80 nm obtained by Scanning Electron Microscope and X-ray diffraction image . From the experiment we find that the amount of leucocytes in the bloods in the experimental group is considerably...
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