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The work presented here demonstrates the utility of a two-step algorithm for environmental poliovirus surveillance based on: preselection of sewage samples tested for the presence of enteroviral genetic material-RT-PCR assay and detection of infectious viruses by cell culture technique (L20B for polioviruses and RD for polio and other non-polio enteroviruses). RD and L20B cell lines were tested to...
The study has described the history of the research of Listeria, starting from 1924 when it was identified for the first time. Phenotypic and genetic characteristics of Listeria have been described. Furthermore, the occurrence of Listeria in the environment of humans and animals has been presented. Moreover, mechanisms and effectors that influence pathogenesis have been presented as well as the latest...
Insects perfectly fit the flagship principle of animal research – 3R: to reduce (the number of animals), to replace (animals with alternative models) and to refine (methods). Bees have the most important advantages of a model organism: they cause minimal ethical controversy, they have a small and fully known genome, and they permit the use of many experimental techniques. Bees have a fully functional...
Perpendicular Magnetic Anisotropy
In article number 2308724, Xi Shen, Xiufeng Han, Richeng Yu, and co‐workers proposed a strategy for enhancing perpendicular magnetic anisotropy in yttrium iron garnet (YIG) films with only a tiny lattice mismatch by slight oxygen deficiency, which theoretically originates from the reduction of saturation magnetization and the increase of magnetostriction coefficient...
Label‐Free Electroporation
In article number 2310221, Ruiguo Yang and co‐workers propose a porous substrate‐based electroporation platform for high‐throughput and controlled delivery using commercially available cell culture inserts. Transepithelial electrical impedance (TEEI) monitoring was incorporated to the platform, providing insight into the intermediate steps of the electroporation process...
Nanosized Drug Crystals
In article number 2306054, Yohann Corvis and co‐workers describe a combined Quality‐by‐Design/Design of Experiments approach to determine the optimal experimental parameters for formulating curcumin nanocrystals that are uniform in size and stable. The authors used a standardized, reproducible, and robust nanocrystallization protocol for the preparation of therapeutic organic...
2D Peptide Crystals
A dodecapeptide and its two mutants self‐organize to form 2D molecular crystals with oblique symmetries on an atomically flat graphite lattice, each exhibiting an exclusive crystallographic chiral relationship, resulting in a coherent bio/nano hybrid soft interface with the potential to serve as a foundation for future bio/nanodevices. More in article number 2400653, Ayhan Yurtsever,...
Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in the presence of ultrasound to directly kill tumor cells, and concurrently activate anti‐tumor immunity especially after integration with tumor microenvironment (TME)‐engineered...
Hybrid ion capacitors (HIC) are receiving a lot of attention due to their potential to achieve high energy and power densities, but they remain insufficient. It is imperative to explore outstanding and environmentally benign electrode materials to achieve high‐performing HIC systems. Here, a unique boron carbon nitride (BCN)‐based HIC system that comprises a microporous BCN structure and Fe1−xS nanoparticle...
Passivating the electronic defects of metal halide perovskite is regarded as an effective way to improve the power conversion efficiency (PCE) of perovskite solar cells (PVSCs). Here, a series of dipeptide molecules with abundant ─C═O, ─O─ and ─NH functional groups as defects passivators for perovskite films are employed. These dipeptide molecules are utilized to treat the surface of prototype methyl...
The development of ultraviolet circularly polarized light (UVCPL) sources has the potential to benefit plenty of practical applications but remains a challenge due to limitations in available material systems and a limited understanding of the excited state chirality transfer. Herein, by constructing hybrid structures of the chiral perovskite CsPbBr3 nanoplatelets and organic molecules, excited state...
Developing novel substances to synergize with nanozymes is a challenging yet indispensable task to enable the nanozyme‐based therapeutics to tackle individual variations in tumor physicochemical properties. The advancement of machine learning (ML) has provided a useful tool to enhance the accuracy and efficiency in developing synergistic substances. In this study, ML models to mine low‐cytotoxicity...
2D Selectors
In article number 2310158, Yanpeng Liu, Wanlin Guo, and co‐workers devise a 2D graphene/hBN/WSe2 selector that exhibits outstanding bipolar nonlinearity at room‐temperature. Profiting from well‐designed band alignment and proper tunneling barrier, the selector undergoes direct tunneling at low bias, and Fowler‐Nordheim tunneling at high bias. This proof‐of‐concept demonstration opens...
Shape memory hydrogels provide a worldwide scope for functional soft materials. However, most shape memory hydrogels exhibit poor mechanical properties, leading to low actuation strength, which severely limits their applications in smart biomimetic devices. Herein, a strategy for muscle‐inspired shape memory‐oriented polyvinyl alcohol (PVA)‐natural rubber latex (NRL) hydrogel (OPNH) with multiscale...
Gold Nanoparticles
In article number 2309919, Julie B. Zimmerman and co‐workers present a new multiplexable synthesis of gold nanoparticles in an aqueous system using sodium oleate as a reductant and coating agent. Using this approach, arrays of size‐controlled (8–30 nm) nanoparticles, up to 10 mM Au concentration, were synthesized in 96‐well plates in a thermal cycler. Synthesis scale‐up to 0.5 g...
Self‐organizing solid‐binding peptides on atomically flat solid surfaces offer a unique bio/nano hybrid platform, useful for understanding the basic nature of biology/solid coupling and their practical applications. The surface behavior of peptides is determined by their molecular folding, which is influenced by various factors and is challenging to study. Here, the effect of charged amino acids is...
Controlling the formation of supramolecular protein assemblies and endowing them with new properties that can lead to novel functional materials is an important but challenging task. In this work, a new hybrid polyoxometalate is designed to induce controlled intermolecular bridging between biotin‐binding proteins. Such bridging interactions lead to the formation of supramolecular protein assemblies...
Rational tailoring of the electronic structure at the defined active center of reconstructed metal (oxy)hydroxides (MOOH) during oxygen evolution reaction (OER) remains a challenge. With the guidance of density functional theory (DFT), herein a dual‐site regulatory strategy is reported to tailor the d‐band center of the Co site in CoOOH via the controlled electronic transfer at the Ru─O─Co─O─Fe bonding...