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Dental caries is a multifactorial chronic disease resulting from the intricate interplay among acid‐generating bacteria, fermentable carbohydrates, and several host factors such as saliva. Saliva comprises several proteins which could be utilized as biomarkers for caries prevention, diagnosis, and prognosis. Mass spectrometry‐based salivary proteomics approaches, owing to their sensitivity, provide...
The enzyme α‐amylase has long been a commonly targeted protein in serological tests for saliva. While being especially abundant in saliva, α‐amylase is detectable in vaginal secretions, sweat, fecal matter, breast milk and other matrices. As a result, assays for α‐amylase only provide a presumptive indication of saliva. The availability of mass spectrometry‐based tools for the detection of less abundant,...