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Parkinson’s disease is characterized by the selective degeneration of neuromelanin-containing dopaminergic neurons in the substantia nigra and locus coeruleus. Although the cause of this disease remains unknown, several transition metals, including manganese and copper, have been associated with the development of the atypical form of Parkinsonism, and iron accumulation has been associated with the...
Autopsied liver tissue samples collected from 42 males and 31 females were analyzed for copper, manganese and zinc using atomic absorption spectrometry (AAS). With the exception of two liver samples for which the copper levels were determined to be 74.8 and 104.0 μg/g (dry weight), hepatic copper concentrations were found to range from 1.7 to 32.4 μg/g with a mean concentration of 14.2 μg/g and standard...
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