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Diagnosis and treatment of breast cancer is a complicated task which is aggravated by managing the information generated during these processes. All this information would be much more useful if it would be correctly managed in an efficient and well-structured information system. A Conceptual Schema of Breast Cancer in which all the concepts of the domain of diagnosis and treatment of this disease...
Breast cancer is one of the most common cancers worldwide. In developed countries, among one in eight women develop breast cancer at some stage of their life. Early diagnosis of breast cancer plays a very important role in treatment of the disease. With the goal of identifying genes that are more correlated with the prognosis of breast cancer, we use data mining techniques to study the gene expression...
Survival analysis is an important part of medical statistics or for the study of failures in mechanical systems. The latter is called reliability analysis in engineering. This paper addresses the survival analysis in medical research. In this context of medical research, the survival analysis is frequently used to define prognostic indices for survival or recurrence of a disease, and to study outcome...
Partial AUC (pAUC) represents the area with a restricted range of specificity (e.g. low false positive rate). It may identify important regional differentiated genes missed by full-range analysis. Unlike the popular t-test, which is based on the mean difference and the standard deviation between the disease and health groups, pAUC based test statistic relies on the rank of a gene in different samples...
Computer-aided prognosis (CAP) is a new and exciting complement to the field of computer-aided diagnosis (CAD) and involves developing computerized image analysis and multi-modal data fusion algorithms for helping physicians predict disease outcome and patient survival. At the Laboratory for Computational Imaging and Bioinformatics (LCIB) at Rutgers University we have been developing computerized...
With the development of modern science, the goal of medical research is not limit to explore a type of disease but more accurate multi-subtypes of this disease. For example breast cancer can be divided into three different subtypes: BRCA1, BRCA2 and Sporadic. Previous work only focuses on distinguishing several pairs of tumors. However, the simultaneous distinguish across multiple disease types has...
A new targeted therapy has been developed to deliver chemotherapy directly to the lymph nodes for treatment of lymphatic metastasis. Localization of the treatment was accomplished by using calcium phosphate (CaP) nanoparticles as the delivery vehicle. The CaP-nano conjugates, with adsorbed chemotherapy on the particle exterior, were injected into mouse primary tumors known to metastasize to the draining...
We develop a novel method to identify patients 'with different disease risk level. Our method estimates the optimal partition (cutoff) of a single gene's expression level by maximizing the separation of the survival curves related to the high- and low risk of the disease behavior. We extend our approach to construct two-gene signatures, which can exhibit synergetic influence on patient survival. Using...
Circulating tumor cells (CTCs) in peripheral blood has clinical significance in highlighting disease status for cancer patients. Thus analyzing blood samples, a commonly extracted body fluids in any health test, can be very helpful in prognosis. Here, we present a microdevice that permits separation of CTCs and blood constituents via their distinctively different biorheology. No functional modifications...
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