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Purpose: CD151, one of tetraspanins has been suggested to regulate cancer invasion and metastasis. We examined whether it is expressed in primary breast carcinoma and whether has relation with integrina3e1 and MMP7. Methods: By using immunohisto chemical S-P method, the expressions of CD151, integrina3e1 and MMP7 proteins in breast cancer tissue micro array (TMA) were tested. Their correlations with...
In this work we assess the feasibility of focused electromagnetic ablation of breast cancer. In our approach we consider two degrees of freedom, namely the bolus permittivity and the operational frequency. The electric fields in a two-dimensional configuration are computed per source using the iterative conjugate gradient method. The fields are subsequently focused in two lesions. The focusing performance...
Ultra-wideband (UWB) microwave imaging is a promising technique for detecting early stage breast cancer, which exploits the significant contrast in dielectric properties between normal and malignant breast tissues. In this paper, we have proposed a new modified compensation method and beamforming technique for microwave imaging. We used a three dimensional (3-D) Finite Integration Technique (FIT)...
Identification of genes and pathways involving in diseases and physiological conditions is a major task in systems biology. In this study, we develop a new non-parameter Ising model to integrate protein-protein interaction network and microarray data for identifying differentially expressed (DE) genes. We also propose a simulated annealing algorithm to find the optimal configuration of the Ising model...
This contribution presents a selection of phantom and clinical results from a prototype multistatic imaging radar designed and built at Bristol. Complex phantoms are employed in order to approximate the difficulty in imaging breast tissue, however, even so, imaging in a clinical environment poses particular challenges.
Based on the geometrical characteristics of the female breast tissue, a bioheat transfer model is setup to study the surface temperature expression of the breast with a malignant tumor. Resort to the finite element analysis, effects of geometrical parameters of the tumor (the location and the size) and thermal diagnosis conditions (the environmental temperature and the convective heat transfer coefficient)...
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