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Cancer progression depends on both cell-intrinsic processes and interactions between different cell types. However, large-scale assessment of cell type composition and molecular profiles of individual cell types within tumors remains challenging. To address this, we developed epigenomic deconvolution (EDec), an in silico method that infers cell type composition of complex tissues as well as DNA methylation...
The tissue-specific translation elongation factor eEF1A2 was recently shown to be a potential oncoprotein that is over expressed in human ovarian and breast cancer. eEF1A2 encoded on chromosome 20 shares similar features to the near-ubiquitously expressed eEF1A1, a closely-related isoform encoded on chromosome 6. It is still unknown why the tissue-specific eEF1A2 should have oncogenic properties in...
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