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Methyl-CpG binding domain-based capture followed by sequencing (MBDCap-seq) is a cost-effective method for genome-wide methylation analyses especially in CpG-rich regions. In this study, we developed BIMMER, a BI-layer hidden Markov model for differential Methylation Regions (DMRs) identification BIMMER using MBDCap-seq samples derived from two different phenotypes. BIMMER models and generates a posterior...
We present a computational method that combines genome-wide DNA methylation and copy number variation data in an integrated fashion with the aim of finding mechanistic associations between genome instability and local DNA methylation changes. The method is applied to Luminal A breast cancer early-stage tumour samples and focuses on methylation events occurring at frequently rearranged genome locations...
The tissue-specific translation elongation factor eEF1A2 was recently shown to be a potential oncoprotein that is over expressed in human ovarian and breast cancer. eEF1A2 encoded on chromosome 20 shares similar features to the near-ubiquitously expressed eEF1A1, a closely-related isoform encoded on chromosome 6. It is still unknown why the tissue-specific eEF1A2 should have oncogenic properties in...
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