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Background
High‐dose methotrexate (HD‐MTX; 5000 mg/m2) is an important component of curative therapy in many treatment regimens for high‐risk pediatric acute lymphoblastic leukemia (ALL). However, methotrexate therapy can result in dose‐limiting neurotoxicity, which may disproportionately affect Latino children. This study evaluated risk factors for neurotoxicity after HD‐MTX in an ethnically diverse...
Aim
To compare clinical characteristics and identify factors predictive of resistance to initial treatment with methotrexate‐folinic acid (MTX‐FA) in women with low‐risk gestational trophoblastic neoplasia (GTN).
Methods
Retrospective chart reviews were conducted in patients diagnosed with low‐risk GTN who were treated with MTX‐FA at Siriraj Hospital between 2002 and 2018. Demographic data, disease...