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Severe mechanical trauma of the spinal cord induces a secondary injury response that contributes to post injury cell death and the formation of barriers inhibitory to neuronal regeneration. It is believed that engineered scaffolds produce favorable results when they mimic the properties of the tissue that they are aiming to replicate. Alginate hydrogels have been shown to be beneficial in a number...
Low-power laser irradiation (LPLI), a non-damage physical therapy, which has been used clinically for decades of years, was shown to promote cell proliferation and prevent apoptosis. Apoptosis is a contributing pathophysiological mechanism of Alzheimer's disease (AD). However, whether LPLI could prevent apoptosis in AD model is not clear. In this study, we demonstrated for the first time that LPLI...
The model of different level's sub-chronic aluminum intoxication in chickens was established by continuous peritoneal injection of fixed volume and different gradient aluminum trichloride (AlCl3). The apoptosis of cerebrum neurocytes was detected by agarose gel electrophor-esis, AO/EB double fluorescent staining and flow cytometry. The results showed that: (1) The typical apoptosis and necrosis of...
Knockout mouse forms a great tool in identifying the perturbations in signaling networks. Retinal degeneration and signaling networks involved in it have long been an intriguing question. We ventured out in finding the networks by using rhodopsin kinase (Rhok) or arrestin (Sag) knockout and as well as both the knockouts in mice retina. Our screening analysis revealed that during initial exposure to...
This paper discusses the biocompatibility of an implanted cuff electrode. Long lasting stimulation-induced depression of neuronal excitability (SIDNE) and apoptosis are also discussed
Mitochondrial permeability transition (MPT) is an intracellular event that is closely related to apoptosis and necrosis. However, whether this process underlies the recently reported neuroprotective potency of mitochondrial potassium channel openers applied in vivo remains uncertain. This study aims to clarify this issue by determining the effects of potassium channel openers on MPT dynamics in vitro...
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