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Cancer is the second leading cause of death in the United States. It is believed that many people develop cancers in their lifetime but the immune system kills these cells without the need for outside treatments. In cancer progression, however, tumor cells may evade the immune system by a mechanism that is not fully understood. Soluble fibrin (sFn), a marker for disseminated intravascular coagulation,...
Nitroreductase gene NOR1 is possibly involved in the chemical carcinogenesis of hepatic cancer and nasopharyngeal carcinoma. We have demonstrted that NOR1 overexpression could convert monofunction alalkylating agent, CB1954 ([5-aziridin-1-yl]-2,4-dinitrobenzamide) into a toxic form by reduction of the 4-nitro group of CB1954 and enhancing cell killing in nasopharyngeal carcinoma(NPC) cell line CNE...
Glioma is the most frequently occurring primary brain tumor in neurosurgery. The PTEN tumor suppressor gene has an essential biological role in the formation of gliomas. The levels of extrons expression of PTEN mRNA in gliomas maybe have some difference with normal brain tissues. In addition, the expression of PTEN protein maybe various among different histological grade gliomas. In this regard, the...
The effects of three structurally related flavonols (kaempferol, quercetin, myricetin) on anti-proliferation and cell cycle arrest in human oesophageal adenocarcinoma OE33 cells were determined and compared by MTT assay and flow cytometry analysis. The results showed that three flavonols not only inhibited proliferation but also induced G2/M arrest in OE33 cells. Moreover, G2/M arrest-inducing activity...
Malignant glioma, the most common type of primary central nervous system (CNS) cancer, has consistently proven unresponsive to chemotherapy. This is due partly to the physiological barriers in place to protect the brain from outside infection and partly due to the changes in gene expression that typify pathogenesis in glioma. One example of such a change in gene expression is the constitutive activation...
For almost three decades, cancer was thought to result from changes in the structure and/or expression of protein coding genes. The discovery of thousands of genes that produce noncoding RNA (ncRNA) transcripts in the past few years suggested that the molecular biology of cancer is much more complex. MicroRNAs (miRNAs), an important group of ncRNAs, have recently been associated with tumorigenesis...
Intrinsically disordered proteins lack stable tertiary and/or secondary structure under physiological conditions in vitro. They are highly abundant in nature, with ~25-30% of eukaryotic proteins being mostly disordered, and with >50% of eukaryotic proteins and > 70% of signaling proteins having long disordered regions. Functional repertoire of intrinsically disordered proteins is very broad...
Many studies have examined the biological activities of Alpha-fetoprotein (AFP); however, the modulatory role of AFP in neoplastic growth remains unclear. Three hairpin siRNA expressing plasmids (pSIREN-DNR-DsRed-Express Donor-Vector-AFP-siRNAl/2/3) were constructed and transfected into FU97(AFP-producing gastric adenocarcinoma cell line). At 48h after transfection, the silencing efficiency to AFP...
The following topics are dealt with: protein-protein interaction; cancer informatics; disease informatics; protein folding; gene networks; biosequence analysis; biochemical modeling; microarray analysis; biological theory; medical informatics; RNA structure; and RNA function
We describe the development of a very large-scale causal, computable model of biology and its specific application in the identification of molecular cause and effect hypotheses of mechanisms underlying the effects of androgen stimulation in the LNCaP prostate carcinoma cell line. In contrast to previous LNCaP studies in which genes have been hierarchically clustered by their pattern of response to...
We describe the development of a very large-scale causal, computable model of biology and its specific application in the identification of molecular cause and effect hypotheses of mechanisms underlying the effects of androgen stimulation in the LNCaP prostate carcinoma cell line. In contrast to previous LNCaP studies in which genes have been hierarchically clustered by their pattern of response to...
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