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Protein signaling networks play a central role in transcriptional regulation and the etiology of many diseases. Statistical methods, particularly Bayesian networks, have been widely used to model cell signaling, mostly for model organisms and with focus on uncovering connectivity rather than inferring aberrations. Extensions to mammalian systems have not yielded compelling results, due likely to greatly...
An increasing number of studies have profiled gene expressions in tumor specimens using distinct microarray platforms and analysis techniques. With the accumulating amount of microarray data, one of the most challenging tasks is to develop robust statistical models to integrate their findings. We compare some recent methodologies on the field, with respect to ER status, and focus on a unified among...
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