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Herpes virus entry mediator (HVEM) is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on many immune cells. In this study we show that treatment of human monocytes with recombinant human LIGHT (rhLIGHT) induces rapid Ca2+ influx in an HVEM-specific manner in parallel with the TNF-alpha production and enhances the bactericidal activities of monocytes. Immunoprecipitation...
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