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We developed a portable odorant detection system composed of collagen micro-pillars with cells expressing olfactory receptors and a CMOS imaging sensor; the CMOS imaging sensor caught fluorescence signals of Ca2+ increased by odorant molecules. While low sensitiveness of the CMOS imaging sensor was insufficient to detect the fluorescent signal from a single cell, the odorant detection system achieved...
In this study, we investigated the ionic current rectification of glass nanopipettes modified with bovine serum albumin glutaraldehyde (BSA-GA) artificial membrane using solutions with various pHs. Ionic current rectification is a phenomenon that is observed with nanopores as asymmetric I-V curves, where the ionic currents recorded through a nanopore differ at the same magnitude of applied electrical...
Nanopore sensing has been widely researched owing to its single molecule sensitivity. In this work, we have demonstrated the potential application of a relatively low-cost single borosilicate nanopore-based sensor for simultaneous detection of multiple charged particles with various diameters.
Giant unilamellar vesicles (GUVs), or giant liposomes, are very similar to actual cells about the size (∼1 – 100 µm); therefore, GUVs have much larger trapping volumes than conventional liposomes (large unilamellar vesicles, LUVs; ∼100 nm). Albeit having such large trapping volumes, GUVs are rarely employed as microcapsules for biomedical purposes because of their difficulties of the preparation in...
Elastin-Like Polypeptides are an interesting class of recombinant proteins that mimic elastin. Here we present some data about phase transition properties and particle formation features of the recombinantly expressed Human Elastin-Like polypeptide (HELP). This macromolecule shows a promising potential as vehicle for delivery and controlled release of active compounds.
Using a combination of an oblique-incidence reflectivity difference (OI-RD) scanning microscope and a customized 8-chamber sample cartridge, we detect 300 surface-immobilized molecular targets reacting with up to 8 different analytes simultaneously on a single slide.
We investigated surface chemistry platforms for immobilizing two types of synthetic, small-molecule compound libraries, each with over 6000 compounds, and for screening these compounds for potential proteins ligands by a label-free optical scanning microscope.
Surface-enhanced Raman spectroscopy (SERS) has received renewed interest in recent years in fields such as trace analysis, biorelated diagnosis, and living cell study. However, the interference of impurities left on the surface from the preparation process of substrates limits to some extent the application of SERS. In the present paper, we propose a method to prepare clean SERS substrates by a combined...
Objective-type total internal reflection fluorescence technique and Gaussian fit single particle tracking algorithm have been used to study the constrained Brownian motion characteristics of single fluorescent microspheres of 40 nm diameter in real-time. Three-dimensional tracking has been realized from the two-dimensional images by utilizing the exponential decay of the fluorescence intensity excited...
Pathological thrombus formation is initiated by the interaction of blood platelets to immobilized proteins at the vessel wall. Platelet surface adhesion leads to biochemical activation and structural reorganization resulting in spreading of the platelet across the adhesive surface. Extensive studies have been carried out to examine platelet spreading responses on continuous substrates but little is...
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