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We are developing an approach called in toto imaging whose goal is to track all the cell movements and divisions that give rise to an embryo. We can also capture protein expression and localization throughout development using GFP transgenics. Our long term goal is to integrate these data into a “Digital Fish” that shows how the genetic circuits encoded in the genome turn an egg into an embryo. We...
The local three-dimensional (3D) microenvironment of a cell is known to affect it during various processes such as tissue morphogenesis, wound healing and cancer progression. However, the structural properties of the 3D microenvironment's extracellular matrix (ECM) does not usually change after the initial properties are set. This paper presents a method to dynamically and reversibly modify 3D ECM...
We aimed to create an autonomous on-chip system that selectively captures and transports lipid vesicles (liposomes) by using machinery that mimics biological systems. By exploiting DNA hybridization and biomolecular-motor-based motility, we demonstrate that single-stranded DNA-labeled microtubules, gliding on kinesin-coated surfaces, acted as cargo transporters, and single-stranded DNA-labeled cargo...
In cell biology, modern imaging techniques using fluorescence microscopy allow to visualize specific nuclear structures in situ in the same cell nucleus. Hence, distances between these structures can be evaluated, in particular co-localization can be investigated. When the nucleus alters its global shape, especially if the structures are imaged sequentially, the distances are changing as well and...
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