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Cancer cell migration represents an essential step toward metastasis and cancer deaths. However, conventional drug discovery focuses on cytotoxic and growth‐inhibiting compounds rather than inhibitors of migration. Drug screening assays generally measure the average response of many cells, masking distinct cell populations that drive metastasis and resist treatments. Here, this work presents a high‐throughput...
High‐Throughput Cellular Heterogeneity
In article number 2206754, Yu‐Chih Chen and co‐workers present a microfluidic cell migration platform that coordinates robotic liquid handling and computer vision for rapidly quantifying individual cellular motility. The high‐throughput single‐cell screening experiments reveal that many compounds inhibit migration of most cells while leaving fast‐moving subpopulations...
Breast cancer is known as the most common type of invasive cancer in women. It is well‐known that phenolic compounds play an important role in the treatment of this disease. This study hypothesized that isoeugenol based two polyphenolic compounds 1 and 2 exerts its anti‐proliferative effects through the induction of apoptosis and cell migration arrest on human breast cancer cell. Based on this hypothesis,...
Arylamine N‐acetyltransferase 1 (NAT1) is frequently upregulated in breast cancer. Previous studies showed that inhibition or depletion of NAT1 in breast cancer cells diminishes anchorage‐independent growth in culture, suggesting that NAT1 contributes to breast cancer growth and metastasis. To further investigate the contribution of NAT1 to growth and cell invasive/migratory behavior, we subjected...