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micoRNA (miRNA) is a vital class of non-coding RNA genes, which participates in post-transcriptional gene regulation in eukaryotic cell. Interestingly, some close relationships between miRNA expression levels and several human diseases like cancers have been recently uncovered. Difficulties of identifying miRNAs via direct experimental method due to their special and temporal expression patterns make...
In the standard support vector machines for classification, training sets with uneven class sizes results in classification biases towards the class with the large training size. That is to say, the larger the training sample size for one class is, the smaller its corresponding classification error rate is, while the smaller the sample size, the larger the classification error rate. The main causes...
This article introduces a novel method for reducing dimensional complexity of classification problems which are frequently present in gene microarray analysis. Revealing the most relevant subset of genes among few thousands of analyzed genes is necessary to get accurate disease classification. Attribute (gene) filter was developed for such a purpose. The filter, first introduced as mutual information...
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