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Background Glaucoma is a complex, multifactorial disease where apoptosis, microglia activation, and inflammation have been linked to the death of retinal ganglion cells (RGCs) and axon degeneration. We demonstrated previously that FasL-Fas signaling was required for axon degeneration and death of RGCs in chronic and inducible mouse models of glaucoma and that Fas activation triggered RGC apoptosis,...
Das zelluläre Suizidprogramm (Apoptose) ist sowohl für viele physiologische Vorgänge von der embryonalen Entwicklung bis zum Altern, als auch für die Pathogenese und den Verlauf eines weiten Spektrums von Krankheiten von großer Wichtigkeit. Hierzu zählen nicht zuletzt auch chronisch neurodegenerative Prozesse, zu denen auch die erworbene und erbliche Degeneration von Photorezeptorzellen und retinalen...
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