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The objective of this study was to assess the ability of tissue engineered cartilage to adhere to and integrate with porous polyethylene (PPE) in vivo and to evaluate the biomechanical integrity of the bond formed at the interface. Porcine auricular, articular, and costal chondrocytes were suspended in fibrin gel polymer and placed between discs of PPE to form tri‐layer constructs. Controls consisted...
Biodegradable polymers have been widely used as scaffolding materials to regenerate new tissues. To mimic natural extracellular matrix architecture, a novel highly porous structure, which is a three-dimensional interconnected fibrous network with a fiber diameter ranging from 100 to 500 nm, has been created from poly (L-lactic acid) in this work. These fibrous matrices were prepared from the polymer...
Today, one of the limitations associated with cartilage grafting is the lack of bonding between the implanted materials and the natural tissue. Helical rosette nanotubes (HRNs) are novel biomimetic self-assembled supramolecular structures whose basic building blocks are DNA base-pairs, which can solidify into a viscous gel at body temperatures in short periods of time. HRNs are similar in size to...
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