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Extracted from Chinese herbal medicine Tripterygium wilfordii Hook f., triptolide is an active compound with positive therapeutic effects on immune-regulated disease of rheumatoid arthritis. However, the male reproductive toxicity blocks its wider clinical applications. With the mechanisms of male toxicity is still obscure, it is difficult to tackle its toxicity. In this study, triptolide's male reproductive...
To investigate the regulation of Ets family transcription factors Ets1 and Ets2 on the development of mouse testis and elucidate the effects of Ets1 and Ets2 on self-renewal and differentiation of spermatogonial stem cells. Mouse testis tissues were collected from specific developmental stages including the postnatal days 1, 5, 10, 15, 20, 25, 30, 35, 40, 50 and 70; busulfan peritoneal injection was...
Single cell gel electrophoresis (SCGE) was used in the present study to detect the DNA damage induced by Di-(2- ethylhexyl)phthalate (DEHP) in three organs (liver, testis, and brain) of mice. The results showed that DEHP could induce DNA damage in mice, and the damage effect increased with the concentrations of DEHP, indicating the dose-dependent manner of DEHP toxicity. A significant DNA breakage...
The preventive and therapeutic effects of DiLong oblatum are observed on free radical oxidative injury in mouse brain and testis after EMP radiation. Activity of SOD was detected by NBT method and content of MDA was detected by TBA method. Compared with control group, activity of SOD in brain and testis decreased significantly and content of MDA in brain and testis increased significantly after EMP...
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