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Background
Platelet‐transfusion refractory (PR) patients do not achieve expected post‐transfusion platelet counts. We investigate suspected PR patients with post‐transfusion platelet counts, indirect platelet antibody screens (ind‐PAS), Class I HLA antibody tests (HLA‐Scr), and physical platelet crossmatch (PXM) studies.
Study Design and Methods
The three following cases describe possible pitfalls...
Background
Cryoprecipitate (CRY) is widely used for treating acquired hypofibrinogenemia. During our study to determine an optimal preparation method, we noticed that the measurement of fibrinogen concentration in CRY had a risk of overestimation. We analyzed this condition and mechanism.
Study Design and Methods
CRY was prepared from fresh frozen plasma (FFP) under four conditions: A, 30 h thawing...
Background
The updated guidance for improving bacterial detection (BD) of platelets has included the implementation of large‐volume delayed sampling (LVDS) with the addition of anaerobic culture bottles (BPNs) and sampling of each platelet split product.
Methods
The frequency of BD was reviewed during this LVDS time period in comparison with pre‐LVDS and the Post‐Approval Surveillance Study of...
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