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Key points
As reactivation of the fetal gene program has been implicated in pathological remodelling during heart failure (HF), we examined whether cardiomyocyte subcellular structure and function revert to an immature phenotype during this disease.
Surface and internal membrane structures appeared gradually during development, and returned to a juvenile state during HF. Similarly, dyadic junctions...
Key points
The physiological maturation of auditory hair cells and their innervation requires precise temporal and spatial control of cell differentiation.
The transcription factor gata3 is essential for the earliest stages of auditory system development and for survival and synaptogenesis in auditory sensory afferent neurons.
We show that during postnatal development in the mouse inner ear gata3...
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