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Heart failure (HF) is a complex clinical syndrome affecting roughly 26 million people worldwide. Increased sympathetic drive is a hallmark of HF and is associated with disease progression and higher mortality risk. Several mechanisms contribute to enhanced sympathetic activity in HF, but these pathways are still incompletely understood. Previous work suggests that inflammation and activation of the...
Key points
Reducing Na+ intake reduces the partial pressure of oxygen in the renal cortex and activates the renin‐angiotensin‐aldosterone system.
In the absence of high blood pressure, these consequences of dietary Na+ reduction may be detrimental for the kidney.
In a normotensive animal experimental model, reducing Na+ intake for 2 weeks increased renal oxygen consumption, which was normalized...
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