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Microtubule dynamics have been shown to contribute to neurite outgrowth, branching, and guidance. Stathmin 1 is a potent microtubule‐destabilizing factor that is involved in the regulation of microtubule dynamics and plays an essential role in neurite elongation and synaptic plasticity. Here, we investigate the expression of stathmin 1 in the brain tissues of patients with intractable temporal lobe...
There is increasing data implicating neuropeptide Y (NPY) in the neurobiology of addiction. This study explored the possible role of NPY in cocaine‐induced behavior using NPY knockout mice. The transgenic mice showed a hypersensitive response to cocaine in three animal models of cocaine addiction. Whether this is due to an observed compensatory increase in striatal dopamine transporter binding or...
[18F]AV‐133 is a novel PET tracer for targeting the vesicular monoamine transporter 2 (VMAT2). The aim of this study is to characterize and quantify the loss of monoamine neurons with [18F]AV‐133 in the MPTP‐lesioned PD mouse model using animal PET imaging and ex vivo quantitative autoradiography (QARG). Methods: Optimal imaging time window of [18F]AV‐133 was first determined in normal C57BL/6 mice...
Methylphenidate (MPH) is a psychostimulant used in the treatment of attention‐deficit/hyperactivity disorder in children and adults. Increasing abuse rates of this drug have raised questions regarding the effects of chronic, high‐dose MPH administration. Although the effects of chronic MPH exposure have been well‐documented in regard to reward‐related behaviors in adolescent and adult animals, there...
TorsinA is an evolutionarily conserved AAA+ ATPase, and human patients with an in‐frame deletion of a single glutamate (ΔE) codon from the encoding gene suffer from autosomal‐dominant, early‐onset generalized DYT1 dystonia. Although only 30–40% of carriers of the mutation show overt motor symptoms, most experience enhanced excitability of the central nervous system. The cellular mechanism responsible...
Interest is rising for animal modeling of impaired behavioral inhibition. Impulsivity and risk proneness, key symptoms of impulse‐control disorders, are classically measured by Intolerance to Delay (ID) and Probabilistic Delivery (PD) tasks, requiring choice between a “Small & Soon” or “Sure” (SS) versus a “Large & Late” or “Luck‐Linked” (LL or LLL, respectively) reinforcer. Several temporal...
The aim of this study was to investigate the effect of age on the distribution of adenosine A1 receptors (A1Rs) and adenosine A2A receptors (A2ARs) in the striatum of healthy subjects using PET imaging with 8‐dicyclopropylmethyl‐1‐[11C]methyl‐3‐propylxanthine ([11C]MPDX) and [7‐methyl‐11C]‐(E)‐8‐(3,4,5‐trimethoxystyryl)‐1,3,7‐trimethylxanthine ([11C]TMSX), respectively. We recruited 8 young (22.0...
The mechanism of agonist‐induced GABAB receptor (GABABR) internalization is not well understood. To investigate this process, we focused on the interaction of GABABR with β‐arrestins, which are key proteins in the internalization of most of the G protein‐coupled receptors, and the agonist‐induced GABABR internalization and the interaction of GABABR with β‐arrestin1 and β‐arrestin2 were investigated...
PET imaging studies of the role of the dopamine D2 receptor family in movement and neuropsychiatric disorders are limited by the use of radioligands that have near‐equal affinities for D2 and D3 receptor subtypes and are susceptible to competition with endogenous dopamine. By contrast, the radioligand [18F]N‐methylbenperidol ([18F]NMB) has high selectivity and affinity for the D2 receptor subtype...
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