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The presumptive unisensory neocortical areas process multisensory information by oscillatory entrainment of neuronal networks via direct cortico‐cortical projections. While neonatal unimodal experience has been identified as necessary for setting up the neuronal networks of multisensory processing, it is still unclear whether early cross‐modal experience equally controls the ontogeny of multisensory...
Synaptic dysfunction and loss is the strongest pathological correlate of cognitive decline in Alzheimer's disease (AD) with increasing evidence implicating neuropathological tau protein in this process. Despite the knowledge that tau spreads through defined synaptic circuits, it is currently unknown whether synapse loss occurs before the accumulation of tau or as a consequence. To address this, we...
Several mutations within SHANK3 gene have been identified in Autism Spectrum Disorder patients and several studies have now started to show that those mutations could impact different brain circuits leading to the heterogeneity of the disease. Here we show that, compared to a mouse model lacking SHANK3 proline‐rich containing isoforms, in a mouse model lacking SHANK3 ANK(yrin)‐domain containing isoforms,...
Pattern separation is a mnemonic process that has been extensively studied over the years. It entails the ability ‐of primarily hippocampal circuits‐ to distinguish between highly similar inputs, via generating different neuronal activity (output) patterns. The dentate gyrus (DG) in particular has long been hypothesized to implement pattern separation by detecting and storing similar inputs as distinct...
The brain's neocortex is anatomically organized into grey and white matter, which are mainly composed by neuronal and glial cells, respectively. The neocortex can be further divided in different Brodmann areas according to their cytoarchitectural organization, which are associated with distinct cortical functions. There is increasing evidence that brain development and function are governed by epigenetic...
The activity of lateral habenula (LHb) represents a substrate for the encoding of negative‐valenced events. The exposure to aversive stimuli in naïve mice is sufficient to trigger a reduction in GABAB‐mediated signaling in the LHb. This is ultimately instrumental for the hyperactivity of LHb neurons and for the establishment of depressive‐like phenotypes. However, the mechanisms responsible for the...
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