The aim of this study was to understand the interactions between anthropometric, kinetic, and kinematic variables and how they determine the 100 m freestyle performance in young swimmers. Twenty‐five adolescent swimmers (15 male and 10 female, aged 15.75 ± 1.01 years) who regularly participated in regional and national competitions were recruited. The 100 m freestyle performance was chosen as the variable to be predicted. A series of anthropometric (hand surface area–HSA), kinetic (thrust and active drag coefficient (CDA)), and kinematic (stroke length (SL); stroke frequency (SF), and swimming speed) variables were measured. Structural equation modeling (via path analysis) was used to develop and test the model. The initial model predicted performance with 90.1% accuracy. All paths were significant (p < 0.05) except the thrust—SL. After deleting this non‐significant path (thrust—SL) and recalculating, the model goodness‐of‐fit improved and all paths were significant (p < 0.05). The predicted performance was 90.2%. Anthropometrics had significant effects on kinetics, which had significant effects on kinematics, and consequently on the 100 m freestyle performance. The cascade of interactions based on this path‐flow model allowed for a meaningful prediction of the 100 m freestyle performance. Based on these results, coaches and swimmers should be aware that the swimming predictors can first meaningfully interact with each other to ultimately predict the 100 m freestyle performance.