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In article number 1503339, F. Li, Y. Song, and co‐workers present an overview of the fabrication and applications of nanoparticle‐patterned assembly by printing methods, including inkjet printing, lithography, imprinting, and extended printing techniques. The assembly process and mechanism on various substrates with distinct wettabilities are summarized, and the perspectives and challenges in this...
By taking advantage of the innate ability of the immune cells to target tumor cells, in article number 1603121, Cheng Dong, Jian Yang, and co‐workers develop a selfpowered immune cell‐mediated theranostic biodegradable photoluminescent poly (lactic acid) (BPLP‐PLA) nanoparticle‐based drug delivery system for melanoma targeting and drug delivery.
Although tremendous efforts have been made on targeted drug delivery systems, current therapy outcomes still suffer from low circulating time and limited targeting efficiency. The integration of cell‐mediated drug delivery and theranostic nanomedicine can potentially improve cancer management in both therapeutic and diagnostic applications. By taking advantage of innate immune cell's ability to target...
Using spectroscopic and thermoelectric characterization, the effect of organic bases on the doping of carbon nanotubes is investigated by Y. Nonoguchi, R. M. Uda, T. Kawai, and co‐workers in article number 1603420. The composite prepared at an appropriate pH shows n‐type transport properties with excellent air stability, demonstrating a green and practical route to n‐type thermoelectric materials...
Water‐dispersed organic base nanoparticles are utilized for the highly stable n‐type doping of single‐walled carbon nanotubes in aqueous dispersion. Long‐term stability is often a critical challenge in the application of n‐type organic conductors. The present n‐type organic materials exhibit almost no degradation in the thermoelectric properties over months, in air.
Aggregation of amyloid‐β protein (Aβ) is a pathological hallmark of Alzheimer's disease (AD), so the inhibition of Aβ aggregation is an important strategy for the prevention and treatment of AD. Herein, we proposed to design molecular hybrids of peptide inhibitors by combining two peptide inhibitors, VVIA and LPFFD, into single sequences and examined their effects on Aβ42 aggregation and cytotoxicity...
Understanding the fundamental biophysics behind protein–nanoparticle (NP) interactions is essential for the design and engineering bio‐NP systems. The authors describe the development of a coarse‐grained protein–NP model that utilizes a structure centric protein model. A key feature of the protein–NP model is the quantitative inclusion of the hydrophobic character of residues in the protein and their...
Antibodies that antagonize cell signaling pathways specific to their targeted receptor are invaluable tools to study and treat malignancies, but their utility is limited by high production costs and treatment dosages. Researchers have shown that antibodies conjugated to nanoparticles display increased affinity for their target relative to freely delivered antibodies due to multivalency, and this study...
There is a pressing need to develop more effective therapeutics to fight cancer. An idyllic chemotherapeutic is expected to overcome drug resistance of tumors and minimize harmful side effects to healthy tissues. Antibody‐functionalized porous silicon nanoparticles loaded with a combination of chemotherapy drug and gold nanoclusters (AuNCs) are developed. These nanocarriers are observed to selectively...
In biological environments, the surface of nanoparticles (NPs) are modified by protein corona (PC) that determines their biological behavior. Unfortunately, in vitro tests still give different PC than in vivo tests causing in vitro–in vivo discrepancy; hence, in vitro studies are not indicative for the NPs' behavior in vivo. Here is demonstrated that PC in vitro is strongly influenced by the type...
Nowadays a large variety of applications are based on solid nanoparticles dispersed in liquids—so called nanofluids. The interaction between the fluid and the nanoparticles plays a decisive role in the physical properties of the nanofluid. A novel approach based on the nonradiative energy transfer between two small luminescent nanocrystals (GdVO4:Nd3+ and GdVO4:Yb3+) dispersed in water is used in...
Efficiently detecting mechanical deformations within materials is critical in a wide range of devices, from micro‐electromechanical systems to larger structures in the aerospace industry. This communication reports the fabrication of new mechanochromic micrometer‐size capsules enabling the detection of strains. These microcapsules are synthesized using an emulsification approach. They are made of...
In multiphoton microscopy, the ongoing trend toward the use of excitation wavelengths spanning the entire near‐infrared range calls for new standards in order to quantify and compare the performances of microscopes. This article describes a new method for characterizing the imaging properties of multiphoton microscopes over a broad range of excitation wavelengths in a straightforward and efficient...
Flexible photodetectors have attracted a great deal of research interest in recent years due to their great possibilities for application in a variety of emerging areas such as flexible, stretchable, implantable, portable, wearable and printed electronics and optoelectronics. Novel functional materials, including materials with zero‐dimensional (0D) and one‐dimensional (1D) inorganic nanostructures,...
Enzyme activity is important for metabolism, cell functions, and treating diseases. However, remote control of enzyme activity in deep tissue remains a challenge. This study demonstrates near‐infrared (NIR) light‐regulated enzyme activity in living cells based on upconverting nanoparticles (UCNPs) and a photoactivatable Ru complex. The Ru complex is a caged enzyme inhibitor that can be activated by...
Metal–organic frameworks (MOFs) are very promising self‐sacrificing templates for the large‐scale fabrication of new functional materials owing to their versatile functionalities and tunable porosities. Most conventional metal oxide electrodes derived from MOFs are limited by the low abundance of incorporated metal elements. This study reports a new strategy for the synthesis of multicomponent active...
In article 1702098, by Bart van Dam, Minjie Li, and co‐workers, single‐dot spectroscopy is used to show that individual carbon dots already exhibit excitation‐dependent photoluminescence, very similar to the ensemble of carbon dots. Characteristic excitation‐dependent emission spectra are identified, indicating the presence of multiple active emission sites within a carbon dot. This shows that it...
Carbon dots (CDs) are carbon‐based fluorescent nanoparticles that can exhibit excitation‐dependent photoluminescence (PL) “tunable” throughout the entire visible range, interesting for optoelectronic and imaging applications. The mechanism underlying this tunable emission remains largely debated, most prominently being ascribed to dot‐to‐dot variations that ultimately lead to excitation‐dependent...
Plant virus nanoparticles are often used to display functional amino acids or small peptides, thus serving as building blocks in application areas as diverse as nanoelectronics, bioimaging, vaccination, drug delivery, and bone differentiation. This is most easily achieved by expressing coat protein fusions, but the assembly of the corresponding virus particles can be hampered by factors such as the...
Two conjugated polymers (CPs) with various compositions of phenylene and benzoselenadiazoben (BSD) are synthesized to have a special emitting property; different fluorescence colors in solution and in the solid states, allowing the resulting conjugated polymer dots (Pdots) to emit different fluorescence colors upon their size variation. The photophysical property of such different‐sized Pdots is investigated...
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