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Immunotherapy aims to activate the cancer patient's immune system for cancer therapy. The whole process of the immune system against cancer referred to as the “cancer immunity cycle”, gives insight into how drugs can be designed to affect every step of the anticancer immune response. Cancer immunotherapy such as immune checkpoint inhibitor (ICI) therapy, cancer vaccines, as well as small molecule...
Exquisite design of RuO2‐based catalysts to simultaneously improve activity and stability under harsh conditions and reduce the Ru dosage is crucial for advancing energy conversion involving oxygen evolution reaction (OER). Herein, a distinctive cobalt‐doped RuOx framework is constructed on Co3O4 nanocones (Co3O4@CoRuOx) as a promising strategy to realize above urgent desires. Extensive experimental...
Lithium–sulfur (Li–S) batteries have attracted considerable attention owing to their extremely high energy densities. However, the application of Li–S batteries has been limited by low sulfur utilization, poor cycle stability, and low rate capability. Accelerating the rapid transformation of polysulfides is an effective approach for addressing these obstacles. In this study, a defect‐rich single‐atom...
Fibrous hydrogels are a key component of soft animal tissues. They support cellular functions and facilitate efficient mechanical communication between cells. Due to their nonlinear mechanical properties, fibrous materials display non‐trivial force propagation at the microscale, that is enhanced compared to that of linear‐elastic materials. In the body, tissues are constantly subjected to external...
Artificial assembly of organic–inorganic heterostructures for electrochemical energy storage at the molecular level is promising, but remains a great challenge. Here, a covalently interlayer‐confined organic (polyaniline [PANI])–inorganic (MoS2) hybrid with a dual charge‐storage mechanism is developed for boosting the reaction kinetics of supercapacitors. Systematic characterizations reveal that PANI...
The interaction between platelets and circulating tumor cells (CTCs) contributes to distal tumor metastasis by protecting CTCs from immunological assault and shear stress, which can be disrupted by nitric oxide (NO) through inhibiting platelet‐mediated adhesion. To eradicate primitive tumors and inhibit CTC‐based pulmonary metastasis, a novel biomimetic nanomedicine (mCuMNO) is designed by encapsulating...
The construction of hollow metallic microspheres with rationally designed building blocks of the metal shell is a promising way to achieve low density and functionality control, but the microengineering of the metallic structures on a micrometer spherical surface is a great challenge. In the present work, a novel and simple calcination‐induced aggregation strategy is developed to realize the distribution...
The practical application of Li‐S batteries is seriously hindered due to its shuttle effect and sluggish redox reaction, which requires a better functional separator to solve the problems. Herein, polypropylene separators modified by MoS2 nanosheets with atomically dispersed nickel (Ni‐MoS2) are prepared to prevent the shuttle effect and facilitate the redox kinetics for Li‐S batteries. Compared with...
Hybrid Strains
The defect‐rich crystalline/amorphous Pd nanosheet aerogel with hybrid microstrain and lattice strain is synthesized by combining laser irradiation in liquid and phosphorus doping methods. The measured mass activity, specific activity and C1‐path selectivity of the Pd nanosheet aerogel are 4.48, 3.06 and 5.06 times higher than those of commercial Pd/C, respectively. More details can...
Micro‐sized silicon (µSi) anode features fewer interfacial side reactions and lower costs compared to nanosized silicon, and has higher commercial value when applied as a lithium‐ion battery (LIB) anode. However, the high localized stress generated during (de)lithiation causes electrode breakdown and performance deterioration of the µSi anode. In this work, hollow graphitic carbons with tailored dual...
Thrombotic diseases have a high rate of mortality and disability, and pose a serious threat to global public health. Currently, most thrombolytic drugs especially protein drugs have a short blood‐circulation time, resulting in low thrombolytic efficiency. Therefore, a platelet membrane (Pm) cloaked nanotube (NT‐RGD/Pm) biomimetic delivery system with enhanced thrombolytic efficiency is designed. Nanotubes...
Introduction of the solid phase method to synthesize biopolymers has revolutionized the field of biological research by enabling efficient production of peptides and oligonucleotides. One of the advantages of this method is the ease of removal of excess production materials from the desired product, as it is immobilized on solid substrate. The DNA origami method utilizes the nature of nucleotide base‐pairing...
Many different types of inorganic materials are processed into nano/microparticles for medical utilization. The impact of selected key characteristics of these particles, including size, shape, and surface chemistries, on biological systems, is frequently studied in clinical contexts. However, one of the most important basic characteristics of these particles, their density, is yet to be investigated...
Two‐dimensional nanofluidic membranes offer great opportunities for developing efficient and robust devices for ionic/water‐nexus energy harvesting. However, low counterion concentration and long pathway through limited ionic flux restrict their output performance. Herein, it is demonstrated that rapid diffusion kinetics can be realized in two‐dimensional nanofluidic membranes by introducing in‐plane...
Metal phase molybdenum disulfide (1T‐MoS2) is considered a promising electrocatalyst for hydrogen evolution reaction (HER) due to its activated basal and superior electrical conductivity. Here, a one‐step solvothermal route is developed to prepare 1T‐MoS2 with expanded layer spacing through the derivatization of a Mo‐based organic framework (Mo‐MOFs). Benefiting from N,N‐dimethylformamide oxide as...
While the solid‐state nanopore shows increasing potential during sensitive and label‐free single molecular analysis, target concentration and signal amplification method is in urgent need. In this article, a solution via designing a model nucleic acid circuit reaction that can produce “Y” shape‐structure three‐way DNA oligomers with controllable size and polymerization degree is proposed. Such a so‐called...
Molecular catalysts have been receiving increasingly attention in the electrochemical CO2 reduction reaction (CO2RR) with attractive features such as precise catalytic sites and tunable ligands. However, the insufficient activity and low selectivity of deep reduction products restrain the utilization of molecular catalysts in CO2RR. Herein, a donor–acceptor modified Cu porphyrin (CuTAPP) is developed,...
Natural polymer‐based sutures have attractive cytocompatibility and degradability in surgical operations. Herein, anionic cellulose nanofibrils (ACNF) and cationic guar gum (CGG) are employed to produce nontoxic CGG/ACNF composite filament with a unique core–shell structure via interfacial polyelectrolyte complexation (IPC) spinning. The comprehensive characterization and application performance of...
Aqueous Potassium Ion Supercapacitors
A covalently interlayer‐confined polyaniline–MoS2 hybrid with a dual charge storage mechanism is developed for supercapacitors. In the hybrid, confined polyaniline induces a favorable phase transition, facilitates cross‐layer electron transfer, and decreases K+ diffusion barrier, thus enabling high electrochemical performance. More details can be found in article...
Anti‐Infection Therapies
In article number 2205471, Jianqing Gao, Fangyuan Li, Daishun Ling, and co‐workers report a silver‐based enzymatic nanoadjuvant (EnzNA) by self‐assembling silver nanoclusters that can modulate intracellular and extracellular infectious microenvironments with pH discrepancy to overcome antimicrobial resistance of pathogens. The EnzNA‐mediated modulation of the infectious microenvironment...
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