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MicroRNAs in exosomes (exosomal miRNAs) have attracted increased attention as cancer biomarkers for early diagnosis and prognosis owing to their stability in body fluids. Since strong association exists between exosomal miRNA expression levels and breast cancer, the development of effective methods that can monitor exosomal miRNA expression both over broad concentration ranges and in ultralow amounts...
In article number 1804968, Kyong Hwa Park, Sang Jun Sim, and co‐workers develop a surface‐enhanced Raman scattering (SERS)‐based ultrasensitive exosomal miRNA detection platform with single‐nucleotide specificity, obtained by enhanced SERS signals from uniform plasmonic head‐flocked gold nanopillar SERS substrate that generates self‐assembled hot spots and enables hybridization between short oligonucleotides...
Exosomes are endosome‐derived vesicles enriched in body fluids such as urine, blood, and saliva. So far, they have been recognized as potential biomarkers for cancer diagnostics. However, the present single‐variate analysis of exosomes has greatly limited the accuracy and specificity of diagnoses. Besides, most diagnostic approaches focus on bulk analysis using lots of exosomes and tend to be less...
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