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In article number 1703707, Claudia Wickleder and co‐workers prevent the formation of Eu3+ during the synthesis of Eu2+ phosphors in the relative redox stable ionic liquid (IL) BmimBF4, and allow the direct precipitation of nanoparticles (NPs) from Eu2+ starting materials. Eu2+ NPs, e.g., BaFCl:Eu2+, are prepared by means of two different synthetic routes in ILs in air.
Functional nanoparticles comprised of liquid metals, such as eutectic gallium indium (EGaIn) and Galinstan, present exciting opportunities in the fields of flexible electronics, sensors, catalysts, and drug delivery systems. Methods used currently for producing liquid metal nanoparticles have significant disadvantages as they rely on both bulky and expensive high‐power sonication probe systems, and...
The increasing number of nanoparticles (NPs) being used in various industries has led to growing concerns of potential hazards that NP exposure can incur on human health. However, its global effects on humans and the underlying mechanisms are not systemically studied. Human embryonic stem cells (hESCs), with the ability to differentiate to any cell types, provide a unique system to assess cellular,...
A fundamental understanding of the interplay between ligand‐removal kinetics and metal aggregation during the formation of platinum nanoparticles (NPs) in atomic layer deposition of Pt on TiO2 nanopowder using trimethyl(methylcyclo‐pentadienyl)platinum(IV) as the precursor and O2 as the coreactant is presented. The growth follows a pathway from single atoms to NPs as a function of the oxygen exposure...
Phototheranostics, which simultaneously combines photodynamic and/or photothermal therapy with deep‐tissue diagnostic imaging, is a promising strategy for the diagnosis and treatment of cancers. Organic dyes with the merits of strong near‐infrared absorbance, high photo‐to‐radical and/or photothermal conversion efficiency, great biocompatibility, ready chemical structure fine‐tuning capability, and...
Under the unmet need of efficient tumor‐targeting drugs for oncology, a recombinant version of the plant toxin ricin (the modular protein T22‐mRTA‐H6) is engineered to self‐assemble as protein‐only, CXCR4‐targeted nanoparticles. The soluble version of the construct self‐organizes as regular 11 nm planar entities that are highly cytotoxic in cultured CXCR4+ cancer cells upon short time exposure, with...
The last decade has seen remarkable advances in the development of drug delivery systems as alternative to parenteral injection‐based delivery of insulin. Neonatal Fc receptor (FcRn)‐mediated transcytosis has been recently proposed as a strategy to increase the transport of drugs across the intestinal epithelium. FcRn‐targeted nanoparticles (NPs) could hijack the FcRn transcytotic pathway and cross...
Inorganic polyphosphate [polyP] has proven to be a promising physiological biopolymer for potential use in regenerative medicine because of its morphogenetic activity and function as an extracellular energy‐donating system. Amorphous Ca2+–polyP nanoparticles [Ca–polyP‐NPs] are characterized by a high zeta potential with −34 mV (at pH 7.4). This should contribute to the stability of suspensions of...
Solid oxide fuel cells (SOFCs) represent the most efficient devices for producing electrical power from fuels. The limit in their application is due to the high operation temperature of conventional SOFC materials. Progress is made toward lower operating temperatures using alternative oxygen‐ion conducting electrolytes, but problems of stability and electronic conductivity still remain. A promising...
Peripheral arterial disease (PAD) is defined as a slow, progressive disorder of the lower extremity arterial vessels characterized by chronic narrowing that often results in occlusion and is associated with loss of functional capacity. Although the PAD occurrence rate is increasing in the elderly population, outcomes with current treatment strategies are suboptimal. Hence, there is an urgent need...
Depositing PBCO nano‐particles on Y‐doped BaZrO3 (BZY) backbones as cathodes for proton‐conducting solid oxide fuel cells provides a powerful strategy to improve the BZY‐based fuel cell performance below 600 °C, allowing a high cell performance for this chemically‐stable electrolyte. In article number 1801231, Lei Bi, Enrico Traversa, and co‐workers demonstrate that keeping the particle size at the...
Nanoactuators are a key component for developing nanomachinery. Here, an electrically driven device yielding actuation stresses exceeding 1 MPa withintegrated optical readout is demonstrated. 10 nm thick Al2O3 electrolyte films are sandwiched between graphene and Au electrodes. These allow reversible room‐temperature solid‐state redox reactions, producing Al metal and O2 gas in a memristive‐type switching...
Targeted delivery of anticancer drugs with nanocarriers can reduce side effects and ameliorate therapeutic efficacy. However, poorly perfused and dysfunctional tumor vessels limit the transport of the payload into solid tumors. The use of tumor‐penetrating nanocarriers might enhance tumor uptake and antitumor effects. A peptide containing a tissue‐penetrating (TP) consensus motif, capable of recognizing...
In article number 1803518, Helmut Cölfen and co‐workers use analytical ultracentrifugation to fabricate tailored nanoparticle gradient materials. Gradients of gold spheres, gold rods, and spherical iron oxide nanoparticles are generated by sedimentation of the nanoparticles in a thermoreversible gelatin matrix. The materials can be simulated in advance and the gradients are detected online by the...
Nanoparticle gradient materials are a unique class of functional materials. They combine the specific properties of nanoparticles with macroscopic materials. A continuous spatial gradient of the nanoparticle concentration leads to diverse physical property profiles. Therefore, these materials have a remarkable potential for applications in optics, electronics, and sensors. A novel approach for the...
In article number 1802618, Joong‐jae Lee, Hak‐Sung Kim, and co‐workers develop an intracellular protein delivery system by sequence specific DNA‐protein interactions for targeted therapy. Engineered nucleoproteins are sequentially assembled onto the surface of gold nanoparticles. The resulting nucleoprotein nanoparticles exhibit highly programmable designability for functional protein loading, and...
With a growing number of intracellular drug targets and the high efficacy of protein therapeutics, the targeted delivery of active proteins with negligible toxicity is a challenging issue in the field of precision medicine. Herein, a programed assembly of nucleoprotein nanoparticles (NNPs) using DNA and zinc fingers (ZnFs) for targeted protein delivery is presented. Two types of ZnFs with different...
Bismuth ferrite harmonic nanoparticles (BFO‐HNPs) are a non‐linear material capable of second‐harmonic generation (SHG). In article number 1803776, Fernanda Ramos‐Gomes, Marietta Andrea Markus, and co‐workers use BFO‐HNPs to visualize macrophages in the lungs of mice with allergic airway inflammation. Using multiphoton microscopy, the intense SHG signals from BFO‐HNPs can track macrophages in the...
Recently, second harmonic generation (SHG) nanomaterials have been generated that are efficiently employed in the classical (NIR) and extended (NIR‐II) near infrared windows using a multiphoton microscope. The aim was to test bismuth ferrite harmonic nanoparticles (BFO‐HNPs) for their ability to monitor pulmonary macrophages in mice. BFO‐loaded MH‐S macrophages are given intratracheally to healthy...
In article number 1805509, Ying‐Wei Yang and co‐workers construct conjugated macrocycle polymer nanoparticles consisting of dual macrocyclic rings, i.e., pillarenes and porphyrins, as alternating strut/node components in the skeleton, followed by the immobilization of Pd nanoparticles via a simple post‐treatment method. The resulting composite nanomaterials exhibit excellent stability, remarkable...
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