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Deep Tumor Penetration
The mAlb780@CaP, when transported to the tumor site, triggers a highly efficient process of transcytosis facilitated by caveolae‐mediated endocytosis and calcium ion‐induced exocytosis. This mechanism yields a versatile platform for photoacoustic (PA) imaging‐guided interventions, enhancing the treatment efficacy for solid tumors by deep tissue penetration. More details can...
Transcytosis is an active transcellular transportation pathway that has garnered interest for overcoming the limited deep penetration of nanomedicines in solid tumors. In this study, a charge‐convertible nanomedicine that facilitates deep penetration into solid tumors via transcytosis is designed. It is an albumin‐based calcium phosphate nanomedicine loaded with IR820 (mAlb‐820@CaP) for high‐resolution...
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