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In native tissues, cellular organization is predominantly anisotropic. Yet, it remains a challenge to engineer anisotropic scaffolds that promote anisotropic cellular organization at macroscopic length scales. To overcome this challenge, an innovative, cheap and easy method to align clinically approved non‐woven surgical microfibrillar scaffolds is presented. The method involves a three‐step process...
In article number 1702650, Vahid Hosseini, Viola Vogel, and co‐workers present an innovative and cheap method to align 3D fibrillar scaffolds for surgical and tissue‐engineering applications. This easy to scale‐up method enables the creation of an aligned and highly porous 3D network of fibers with interconnected pores that are suitable for cell infiltration and alignment, both in vivo and in vitro...
The degradation of intervertebral discs (IVD), a typical hierarchical structured tissue, causes serious neck and back pain. The current methods cannot fully reconstitute the unique structure and function of native IVD. In this study, by reverse reconstruction of the structure of native IVD and bioprinting bacterial cellulose (BC) nanofibers with a high‐throughput optimized micropattern screening microchip,...
The electrohydrodynamic stabilization of direct‐written fluid jets is explored to design and manufacture tissue engineering scaffolds based on their desired fiber dimensions. It is demonstrated that melt electrowriting can fabricate a full spectrum of various fibers with discrete diameters (2–50 µm) using a single nozzle. This change in fiber diameter is digitally controlled by combining the mass...
Growth factors are potent stimuli for regulating cell function in tissue engineering strategies, but spatially patterning their presentation in 3D in a facile manner using a single material is challenging. Micropatterning is an attractive tool to modulate the cellular microenvironment with various biochemical and physical cues and study their effects on stem cell behaviors. Implementing heparin's...
Here, a spotlight is shown on aqueous microgel particles which exhibit a great potential for various biomedical applications such as drug delivery, cell imaging, and tissue engineering. Herein, different synthetic methods to develop microgels with desirable functionality and properties along with degradable strategies to ensure their renal clearance are briefly presented. A special focus is given...
For muscle regeneration, a uniaxially arranged micropattern is important to mimic the structure of the natural extracellular matrix. Recently, cell electrospinning (CE) has been tested to fabricate cell‐laden fibrous structures by embedding cells directly into micro/nanofibers. Although homogenous cell distribution and a reasonable cell viability of the cell‐laden fibrous structure fabricated using...
As a powerful strategy to determine cell fate, cell electrospinning has emerged as a method to encapsulate cells directly into micro/nanofibers. In article number 1803491, Miji Yeo and Geun Hyung Kim develop a cell electrospinning method with a simple modification to generate aligned cell‐laden micro/nanofibers, which achieve not only homogeneous cell distribution with a high cell viability, but also...
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