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Cancer biomarkers are expected to be indicative of the occurrence of certain cancer diseases before the tumors form and metastasize. However, many biomarkers can only be acquired in extremely low concentrations, which are often beyond the limit of detection (LOD) of current instruments and technologies. A practical strategy for nanopore sensing of cancer biomarkers in raw human blood down to the femtomolar...
In article number 1804078, Hai‐Chen Wu and co‐workers develop a strategy for the ultrasensitive detection of cancer biomarkers based on the combination of a sandwich assay, “click” chemistry, and DNA‐assisted nanopore sensing. The limit of detection of the strategy can be as low as the femtomolar level. Furthermore, it can effectively eliminate interferences from plasma proteins and be applied in...
T cells can kill tumor cells by cell surface immunological recognition, but low affinity for tumor‐associated antigens could lead to T cell off‐target effects. Herein, a universal T cell targeting strategy based on bio‐orthogonal chemistry and glycol‐metabolic engineering is introduced to enhance recognition and cytotoxicity of T cells in tumor immunotherapy. Three kinds of bicycle [6.1.0] nonyne...
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