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Self‐assembled DNA origami nanostructures have a high degree of programmable spatial control that enables nanoscale molecular manipulations. A surface‐tethered, flexible DNA nanomesh is reported herein which spontaneously undergoes sharp, dynamic conformational transitions under physiological conditions. The transitions occur between two major macrostates: a spread state dominated by the interaction...
In article number 1805552, Hua Zuo, Chengde Mao, and co‐workers describe an elegant method to assemble DNA microparticles (DNAµPs), relying on self‐assembly of multiple copies of the same, short, component DNA strand. The resulting DNAµPs can present single stranded DNA tails on their surfaces to stimulate innate immune responses and capture other single‐stranded nucleic acids.
Nucleic acid–based functional nanomaterials (NAFN) have been widely used as emerging drug delivery nanocarriers for cancer therapeutics. Considerable works have demonstrated that NAFN can effectively load and protect therapeutic agents, and particularly enable targeting delivery to the tumor site and stimuli‐responsive release. These outstanding performances are due to NAFN's unique properties including...
DNA is a superb molecule for self‐assembly of nanostructures. Often many DNA strands are required for the assembly of one DNA nanostructure. For lowering the cost of synthesizing DNA strands and facilitating the assembly process, it is highly desirable to use a minimal number of unique strands for potential technological applications. Herein, a strategy is reported to assemble a series of DNA microparticles...
This Concept provides an overview of recent developments of DNA‐based nanofabrication and discusses its potential applications in the area of surface engineering. The first part of the paper discusses the strength and limitations of existing DNA‐based nanofabrication methods. The second part highlights several examples of surface engineering applications involving nano‐ and microscale surface textures...
Precise control of DNA base pairing has rapidly developed into a field full of diverse nanoscale structures and devices that are capable of automation, performing molecular analyses, mimicking enzymatic cascades, biosensing, and delivering drugs. This DNA‐based platform has shown the potential of offering novel therapeutics and biomolecular analysis but will ultimately require clever modification...
Biocomputation is the algorithmic manipulation of biomolecules. Nanostructures, most notably DNA nanostructures and nanoparticles, become active substrates for biocomputation when modified with stimuli‐responsive, programmable biomolecular ligands. This approach—biocomputing with nanostructures (“nano‐bio computing”)—allows autonomous control of matter and information at the nanoscale; their dynamic...
DNA nanostructures offer new opportunities for diagnostics, therapeutics and biomolecular analysis. For that purpose, they require special modifications and functionalities. In article number 1805386, Megan E. Kizer, Robert J. Linhardt, Arun Richard Chandrasekaran, and Xing Wang discuss the properties needed to make DNA nanostructures applicable to in vitro and in vivo applications by drawing analogies...
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